Journal ArticleDOI
Investigation of Rules for Dealing With Outliers in Small Samples from the Normal Distribution: I: Estimation of the Mean
Irwin Guttman,Dennis E. Smith +1 more
TLDR
In this paper, the performance of three rules for dealing with outliers in small samples of size n from the normal distribution N(μ, σ2) is investigated when the primary objective of sampling is to obtain an accurate estimate of μ.Abstract:
The performance of three rules for dealing with outliers in small samples of size n from the normal distribution N(μ, σ2) are investigated when the primary objective of sampling is to obtain an accurate estimate of μ. It is assumed that at most one observation in the sample may be biased, arising from either N(μ + aσ, σ2) or N(r, (1 + b)σ2). Performance of each rule is measured in terms of “Protection”, the fractional decrease in the Mean Square Error (MSE) obtained by using the rule when a biased observation actually is present in the sample. Although numerical results have been obtained for n ≤ 10 when σ2 is known, computational difficulties have prevented evaluation of protections when σ2 is unknown except when n = 3.read more
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Journal ArticleDOI
An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice
Charles Preston Neff,Jiehua Zhou,Leila Remling,Jes Kuruvilla,Jane Zhang,Haitang Li,David D. Smith,Piotr Swiderski,John J. Rossi,Ramesh Akkina +9 more
TL;DR: A dual-function aptamer that targets both a HIV-1 surface protein and a critical messenger RNA can inhibit HIV infection in humanized mice and shows that the inhibition of two key molecules crucial for the HIV life cycle can in turn inhibit viral spread, pointing to an alternative therapy for this still burdensome infection.
Journal ArticleDOI
The Interplay Between Sensory Processing Abnormalities, Intolerance of Uncertainty, Anxiety and Restricted and Repetitive Behaviours in Autism Spectrum Disorder
TL;DR: Sensory under responsiveness and sensory over responsiveness were significantly associated with repetitive motor and insistence on sameness behaviours, and the relationships significantly mediated by IU and anxiety were found.
Journal ArticleDOI
Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1.
Laurence J.N. Cooper,Zaid S Al-Kadhimi,Lisa Marie Serrano,Timothy Pfeiffer,Simon Olivares,Adrian Castro,Wen-Chung Chang,Sergio Gonzalez,David D. Smith,Stephen J. Forman,Michael C. Jensen +10 more
TL;DR: Engineered T-APCs are a novel and versatile antigen-delivery system for generating antigen-specific T cells in vitro and enhancing the in vivo effector functioning of CAR-redirected antitumor effector cells.
Journal ArticleDOI
Care and Handling of Univariate or Multivariate Outliners in Detecting Spuriosity—a Bayesian Approach
TL;DR: The objective of this paper is to present a method of detection of spuriosity using a Bayesian approach, and the posterior of the “shift parameter a” is obtained, and it is shown to be a weighted combination of (Univariate) generalized t-distributions.
Journal ArticleDOI
The Subjective Nature of Outlier Rejection Procedures
D. Collett,T. Lewis +1 more
TL;DR: In this article, the authors investigate the subjective nature of outlier procedures and find that there are variations both between individuals in their reaction to surprising values and also between judgments made by the same individual on different occasions.
References
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Journal ArticleDOI
A Note on the Generation of Random Normal Deviates
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Sample Criteria for Testing Outlying Observations
TL;DR: In this article, the significance of the largest observation in a sample of size $n$ from a normal population was investigated and the authors proposed a new statistic, S^2_n/S^2, to test whether the two largest observations are too large.
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Processing Data for Outliers
TL;DR: In this paper, the authors discussed the problem of whether certain observations properly belong in the presentation of measurements obtained by an experimenter and suggested that a consideration of this sort is more properly made at the recording stage or perhaps at the stage of preliminary processing.
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Rejection of Outliers
TL;DR: In this article, a detailed study is made of the effect of routine application of rejection criteria to replicate determinations of a single value, especially for triplicate and quadruplicate determinations.
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Simplified Estimation from Censored Normal Samples
TL;DR: In this article, the mean and standard deviation of a normal distribution from a sample which is censored has been considered by Sarhan and Greenberg [1], who obtained coefficients for best linear systematic statistics.