Journal ArticleDOI
Is Liver Transplantation Justified for the Treatment of Hepatic Malignancies
Kim M. Olthoff,J. Michael Millis,Michael H. Rosove,Leonard I. Goldstein,Kenneth P. Ramming,Ronald W. Busuttil +5 more
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TLDR
It is indicated that orthotopic liver transplants can provide long-term cure and palliation for malignant disease; however, patient selection is extremely important in predicting outcome.Abstract:
• Twenty-eight patients received orthotopic liver transplants for malignant disease between February 1, 1984, and December 31, 1989. Preoperative diagnoses included hepatocellular carcinoma (n = 16), cholangiocarcinoma (n = 3), other primary hepatic tumors (n = 6), and metastatic diseases to the liver (n = 3). Overall actuarial survivals at 6 months, 1 year, and 5 years were 67.3%, 51%, and 31%, respectively. Long-term survival longer than 5 years was achieved in 3 patients. The recurrence rate in patients surviving longer than 3 months is 48% (median, 7 months). Hepatocellular carcinoma and cholangiocarcinoma had the poorest survival and highest recurrence rates. Specific prognostic factors correlating with survival or recurrence could not be elucidated. These results indicate that orthotopic liver transplants can provide long-term cure and palliation for malignant disease; however, patient selection is extremely important in predicting outcome. (Arch Surg.1990;125:1261-1268)read more
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Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
Vincenzo Mazzaferro,Enrico Regalia,Roberto Doci,Salvatore Andreola,A. Pulvirenti,Federico Bozzetti,F. Montalto,Mario Ammatuna,Alberto Morabito,Leandro Gennari +9 more
TL;DR: Liver transplantation is an effective treatment for small, unresectable hepatocellular carcinomas in patients with cirrhosis and after four years, the actuarial survival rate was 75 percent and the rate of recurrence-free survival was 83 percent.
Journal ArticleDOI
Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma
Timothy M. Pawlik,Keith A. Delman,Jean Nicolas Vauthey,David M. Nagorney,Irene Oi-Lin Ng,Iwao Ikai,Yoshio Yamaoka,Jacques Belghiti,Gregory Y. Lauwers,Ronnie T.P. Poon,Eddie K. Abdalla +10 more
TL;DR: In this article, the authors examined the relationship between HCC tumor size and microscopic vascular invasion and histologic grade in a multicenter international database of 1,073 patients who underwent resection of HCC.
Journal ArticleDOI
Liver transplantation for hepatocellular carcinoma: a registry report of the impact of tumor characteristics on outcome.
TL;DR: This analysis has documented three tumor characteristics that strongly impact patient survival after transplantation for HCC, including tumor size greater than 5 cm and the presence of vascular invasion, which confirm several, single-center studies.
Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters
Sasan Roayaie,Jason S. Frischer,Sukru Emre,Thomas M. Fishbein,Patricia A. Sheiner,Max Sung,Charles Miller,Myron Schwartz +7 more
TL;DR: In this article, the authors evaluated the long-term results of liver transplantation for hepatocellular carcinoma (HCC) measuring 5 cm or larger treated in a multimodal adjuvant protocol.
Journal ArticleDOI
Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection.
Antoni Castells,Jordi Bruix,Concepció Brú,Josep Fuster,Ramón Vilana,Miquel Navasa,Carmen Ayuso,Loreto Boix,Josep Visa,Joan Rodés +9 more
TL;DR: It is confirmed that ethanol injection is a useful treatment for patients with solitary small hepatocellular carcinomas and suggest that surgical resection and liver transplantation may achieve better results only after strict candidate selection to reduce mortality and tumor recurrence during follow‐up.
References
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