Journal ArticleDOI
Is there an association between the COMT gene and P300 endophenotypes
Elvira Bramon,Emma Dempster,Sophia Frangou,Colm McDonald,Poppy L. A. Schoenberg,James H. MacCabe,Muriel Walshe,Pak C. Sham,David A. Collier,Robin M. Murray +9 more
Reads0
Chats0
TLDR
P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease, and a strong theoretical case is made for the influence of COMT Val158Met polymorphism on P300 endophenotypes.About:
This article is published in European Psychiatry.The article was published on 2006-01-01. It has received 41 citations till now. The article focuses on the topics: Catechol-O-methyl transferase & Endophenotype.read more
Citations
More filters
Journal ArticleDOI
Neurobiology of schizophrenia.
Christopher A. Ross,Russell L. Margolis,Sarah A. J. Reading,Mikhail V. Pletnikov,Joseph T. Coyle +4 more
TL;DR: In this paper, the authors identify proteins of candidate genetic risk factors for schizophrenia, including dysbindin, neuregulin 1, DAOA, COMT, and DISC1.
Journal ArticleDOI
The endophenotype concept in psychiatric genetics
Jonathan Flint,Marcus R. Munafò +1 more
TL;DR: A review of the genetic architecture of traits in model organisms provides no support for the view that the effect sizes of loci contributing to phenotypes closer to the biological basis of disease is any larger than those contributing to disease itself.
Journal ArticleDOI
Neurophysiological biomarkers for drug development in schizophrenia
TL;DR: Recent advances in neurophysiological techniques provide new opportunities to measure abnormal brain functions in patients with schizophrenia and to compare these with drug-induced alterations, offering unique opportunities for use as translational biomarkers in schizophrenia drug discovery.
Journal ArticleDOI
The cortical generators of P3a and P3b: A LORETA study
TL;DR: Differences in scalp topography and cortical sources suggest that the two P3 components reflect different neural processes, in line with the hypothesis that P3a reflects the automatic allocation of attention, while P3b is related to the effortful processing of task-relevant events.
Journal ArticleDOI
Application of Electroencephalography to the Study of Cognitive and Brain Functions in Schizophrenia
TL;DR: The main purpose is to illustrate that these neurophysiological measures can offer valuable quantitative biological markers of basic pathophysiological mechanisms and cognitive dysfunctions in schizophrenia, yet they may not be specific to current psychiatry's diagnosis and classification.
References
More filters
Journal Article
The ten-twenty electrode system of the international federation
TL;DR: During the First International EEG Congress, London in 1947, it was recommended that Dr. Herbert H. Jasper study methods to standardize the placement of electrodes used in EEG (Jasper 1958).
Journal ArticleDOI
A Diagnostic Interview: The Schedule for Affective Disorders and Schizophrenia
Jean Endicott,Robert L. Spitzer +1 more
TL;DR: Initial scale development and reliability studies of the items and the scale scores are reported on.
Journal ArticleDOI
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
TL;DR: The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
Journal ArticleDOI
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.
Michael F. Egan,Terry E. Goldberg,Bhaskar Kolachana,Joseph H. Callicott,C.M. Mazzanti,Richard E. Straub,David Goldman,Daniel R. Weinberger +7 more
TL;DR: The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia.