Isolation of a New Member of the Ecdysteroid Glycoside Family: 2-Deoxy-20-hydroxyecdysone 22-O-β-D-Glucopyranoside
TLDR
A new ecdysteroid glycoside, 2-deoxy-20-hydroxyecdysone 22-O-beta-D-glucopyranoside, is isolated from the herb Silene italica ssp.Abstract:
A new ecdysteroid glycoside, 2-deoxy-20-hydroxyecdysone 22-O-beta-D-glucopyranoside, is isolated from the herb Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. The compound is purified with multistep chromatography, such as classical column chromatography on alumina and droplet countercurrent distribution. Also, it is expanded using twice low-pressure reversed-phase liquid column chromatography. Chromatography in four steps results in the purified 2-deoxy-20-hydroxyecdysone 22-O-beta-D-glucopyranoside. Two other ecdysteroids have also been separated, including the formerly identified integristerone A and 24(28)-dehydromakisterone A.read more
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Diversity of Secondary Metabolites in the Genus Silene L. (Caryophyllaceae)—Structures, Distribution, and Biological Properties
TL;DR: The genus Silene comprises more than 700 species, which are widely distributed in temperate zones of the Northern Hemisphere, but are also present in Africa and have been introduced in other continents.
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Distribution of phytoecdysteroids in the Caryophyllaceae.
L. N. Zibareva,Vladimir A. Volodin,Zyadilla Saatov,Tamara Savchenko,Pensri Whiting,René Lafont,Laurence Dinan +6 more
TL;DR: It was found that phytoecdysteroids were present predominantly in the Genera Lychnis, Petrocoptis, Sagina and Silene, and close association of ecdysteroid occurrence with certain groups of this tribe was revealed.
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Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter.
Ana Martins,Noémi Tóth,Attila Ványolós,Zoltán Béni,István Zupkó,József Molnár,Mária Báthori,Attila Hunyadi +7 more
TL;DR: The results show the effect of ecdysteroids on MDR cancer cells for the first time and biological significance of the resistance-increasing activity of the most abundant phytoecdysteroid including 20-hydroxyecdysone is yet to be clarified.
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The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review.
TL;DR: The present review has summarized 212 new PEs reported between 1999 and 2019 and critically analyzed the biological, pharmacological, and medicinal properties of PEs to understand the full impact of these phytoconstituents in health and disease.
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Phytoecdysteroids from Silene plants: distribution, diversity and biological (antitumour, antibacterial and antioxidant) activities
TL;DR: The biological (antitumour, antibacterial and antioxidant) activities and the phytoecdysteroids of genus Silene are reviewed and the folk and traditional effects of Silene plants are reported on.
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