Journal ArticleDOI
Isolation of biochemically deficient mutants of bacteria by penicillin.
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This article is published in Journal of the American Chemical Society.The article was published on 1948-12-01. It has received 267 citations till now. The article focuses on the topics: Penicillin & Bacteria.read more
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Journal ArticleDOI
Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.
TL;DR: P15A-derived plasmids were not self-transmissible and were mobilized poorly by Hfr strains; however, mobilization was complemented by the presence of a ColE1 plasmid within the same cell.
Journal ArticleDOI
Mutants of escherichia coli requiring methionine or vitamin b12
TL;DR: Certain biochemical properties of auxotrophicl mutants of Escherichia coli with specific growth requirements for most of the known water-soluble vitamins, as well as of others responding to methionine but not to B,2 are described.
Book ChapterDOI
The Genetics of Aspergillus nidulans
TL;DR: The biochemical genetics of Aspergillus nidulans, though similar to that of Neurospora and Ophiostoma, has revealed interesting differences in detail, e.g., the inability of citrulline to replace ornithine for strains responding to Ornithine or arginine; the unable of tryptophan to replace anthranilic acid for certain strain responding to anthranic acid or nicotinic acid.
Journal ArticleDOI
Genetic recombination in Pseudomonas aeruginosa.
TL;DR: Genetic recombination has been shown to occur in Pseudomonas aeruginosa and, although non-random segregation was found for non-selective markers, it has not yet been possible to draw conclusions concerning gene order or linkage.
Journal ArticleDOI
The rate of killing of Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth.
TL;DR: Slow growing bacteria became progressively more phenotypically tolerant to beta-lactam antibiotics as the generation time was extended, and all killing rates were a constant function of the bacterial generation time.