Journal ArticleDOI
Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats
TLDR
Evidence is provided that OA and UA protect rat myocardium against ischemic insult and the protective effect could be attributed to its antioxidant property and/or to a strengthening of myocardial membrane by its membrane stabilizing action.About:
This article is published in International Journal of Cardiology.The article was published on 2007-06-25. It has received 78 citations till now. The article focuses on the topics: Oleanolic acid & Lipid peroxidation.read more
Citations
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Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
TL;DR: Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.
Journal ArticleDOI
Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats.
TL;DR: CA and CD were cardioprotective in a rat model of ischemic myocardial injury and were attributable to anti-oxidative and anti-inflammatory properties, as well as increased NO.
Journal ArticleDOI
Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes.
TL;DR: It is concluded that ursolic acid, a dietary antioxidant, mediates its protective effect through modulation of UVB-induced reactive oxygen species.
Journal ArticleDOI
Ursolic acid in health and disease
Dae Yun Seo,Sung Ryul Lee,Jun-Won Heo,Mi-Hyun No,Byoung Doo Rhee,Kyung Soo Ko,Hyo-Bum Kwak,Jin Han +7 more
TL;DR: Recent data on the beneficial effects and possible uses of UA in health and disease managements are summarized.
Journal ArticleDOI
Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?
TL;DR: An integrative description of the antidiabetic properties of OA, UA, and BA is provided, evaluating the potential use of these TAs as food supplements or pharmaceutical agents to prevent and/or treat T2DM.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study.
TL;DR: Flavonoids in regularly consumed foods may reduce the risk of death from coronary heart disease in elderly men and showed an inverse relation with incidence of myocardial infarction.
Journal ArticleDOI
Myocardial reperfusion: a double-edged sword?
Journal ArticleDOI
Oxidants and antioxidants: State of the art
TL;DR: In the development of new antioxidant therapies, the important question of how these drugs are incorporated in or commensurate with existing integrated physiologic radical-defense systems should be addressed.
Journal ArticleDOI
Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options
TL;DR: The pathophysiology, clinical manifestations of reperfusion injury to the heart and the possible therapeutic approaches to avoiding any adverse effects are reviewed.