Journal ArticleDOI
J. B. S. Haldane and the origin of life
TLDR
The main ideas put forward by Haldane in this famous text on the origin of life on earth are presented and how they were linked to the recent developments of prebiotic chemistry and molecular biology are shown.Abstract:
In 1929 the British biologist John Burdon Sanderson Haldane published a hypothesis on the origin of life on earth, which was one of the most emblematic of the interwar period. It was a scenario describing the progressive evolution of matter on the primitive earth and the emergence of life. Firstly, this paper presents the main ideas put forward by Haldane in this famous text. The second part makes comparisons between Haldane and Alexander Ivanovitch Oparin's ideas regarding the origins of life (1924). These two theories, apparently very similar, presented distinct conclusions. The third part focusses on Haldane's reflections on the emergence of life during the 1950s and 1960s, and shows how they were linked to the recent developments of prebiotic chemistry and molecular biology.read more
Citations
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Journal ArticleDOI
Systems protobiology: origin of life in lipid catalytic networks.
TL;DR: The invigorated GARD scrutiny presented in this review enhances the validity of autocatalytic sets as a bona fide early evolution scenario and provides essential infrastructure for a paradigm shift towards a systems protobiology view of life's origin.
Journal ArticleDOI
Retinal energy metabolism in health and glaucoma.
TL;DR: There is a consilience of evidence that at least some individuals with glaucoma have impaired RGC energy metabolism, either due to impaired nutrient supply or intrinsic metabolic perturbations, and bioenergetic-based therapy for glauca has a compelling pathophysiological foundation and is supported by recent successes in animal models.
Journal ArticleDOI
Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept
Iuliia A. Antifeeva,Alexander V. Fonin,Anna S. Fefilova,Olesya V. Stepanenko,Olga I. Povarova,Sergey A. Silonov,Irina M. Kuznetsova,Vladimir N. Uversky,Konstantin K. Turoverov +8 more
TL;DR: It is emphasized here that the membrane-less organelles have to combine a certain resistance to the changes in their environment and, at the same time, show high sensitivity to the external signals, which ensures the normal functioning of the cell.
Journal ArticleDOI
Protocells: Milestones and Recent Advances.
Irep Gözen,Elif Senem Köksal,Inga Põldsalu,Lin Xue,Karolína Spustová,Esteban Pedrueza-Villalmanzo,R. G. Ryskulov,Fanda Meng,Aldo Jesorka +8 more
TL;DR: Current protocell concepts and research directions are reviewed, milestones, challenges and existing hypotheses are addressed in the context of conditions on the early Earth, and a concise overview of current protocell research methods are provided.
References
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Journal ArticleDOI
A Production of Amino Acids Under Possible Primitive Earth Conditions
TL;DR: In this study, an apparatus was built to circulate CHI4, NH3, H2O, and H2 past an electric discharge, and the resulting mixture has been tested for amino acids by paper chromatography.
Journal ArticleDOI
The Origin of Life.
TL;DR: In the Middle Ages it was held that although the preparation of a living person, or of something like one in the form of a “homunculus”, in a retort by the mixing and distillation of various chemical substances was extremely difficult and impious, nevertheless it was undoubtedly something which could be done as mentioned in this paper.
Journal ArticleDOI
On the Early Chemical History of the Earth and the Origin of Life.
TL;DR: This work was done under contract N7-onr 434 Task Order III, Naval Department, Office of Naval Research, and made use of a homotopy lemma similar to Spanier's lemma.
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