Keratocyte Phenotype Mediates Proteoglycan Structure A ROLE FOR FIBROBLASTS IN CORNEAL FIBROSIS
TLDR
The qualitatively similar expression of glycosaminoglycans shared by fibroblasts and myofibroblast suggests a role for fibro Blasts in deposition of non-transparent fibrotic tissue in pathological corneas.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-11-14 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Corneal keratocyte & Keratan sulfate.read more
Citations
More filters
Journal ArticleDOI
Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors
Laura E. Sidney,Matthew J. Branch,Siobhán E. Dunphy,Siobhán E. Dunphy,Harminder S Dua,Andrew Hopkinson +5 more
TL;DR: Common traits between cells that express CD34 are explored, including associated markers, morphology and differentiation potential, and key similarities between CD34+ cells are highlighted, with a focus on progenitor activity.
Journal ArticleDOI
The molecular basis of corneal transparency
John R. Hassell,David E. Birk +1 more
TL;DR: The growth factor mediated synthesis ofSeveral different collagen types and the core proteins of several different leucine-rich type proteoglycans are required to produce collagen fibrils with the size and spacing needed for corneal stromal transparency.
Journal ArticleDOI
Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy.
Marcelo V. Netto,Rajiv R. Mohan,Renato Ambrósio,Audrey E. K. Hutcheon,James D. Zieske,Steven E. Wilson +5 more
TL;DR: A better understanding of the complete cascade of events involved in the corneal wound healing process and anomalies that lead to complications is critical to improve the efficacy and safety of refractive surgical procedures.
Journal ArticleDOI
Multipotent stem cells in human corneal stroma.
TL;DR: The results demonstrate the presence of a population of cells in the human corneal stroma expressing stem cell markers and exhibiting multipotent differentiation potential, and appear to be the first human cells identified with keratocyte progenitor potential.
Journal ArticleDOI
Hyaluronan-dependent pericellular matrix.
TL;DR: Time-lapse studies show that pericellular matrix formation facilitates cell detachment and mitotic cell rounding, and the importance of the pericesllular matrix in cellular mechanotransduction and the response to mechanical strain are discussed.
References
More filters
Journal ArticleDOI
Myofibroblasts. I. Paracrine cells important in health and disease.
TL;DR: Myofibroblasts are a unique group of smooth-muscle-like fibro-blasts that have a similar appearance and function regardless of their tissue of residence as discussed by the authors.
Journal ArticleDOI
Myofibroblasts differentiate from fibroblasts when plated at low density
TL;DR: It is concluded that myofibroblast differentiation can be induced in fibroblasts by plating at low density, in which at least two factors interact: loss of cell contact and the presence of TGF-beta.
Journal ArticleDOI
Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast
TL;DR: It is demonstrated that TGF-beta1 promoted a dose-dependent increase in the generation of contractile force in myofibroblasts and a concomitant increased in the expression of alpha-sm actin, and that this enhancement occurred prior to, and independent of, alpha-Sm actin expression.
Journal ArticleDOI
The cellular basis of corneal transparency: Evidence for 'corneal crystallins'
James V. Jester,T. Moller-Pedersen,Jiying Huang,C. M. Sax,W. T. Kays,H. D. Cavangh,Walter M Petroll,J. Piatigorsky +7 more
TL;DR: The results suggest that corneal cells, like lens cells, may preferentially express water-soluble proteins, often enzymes, for controlling their optical properties.
Journal ArticleDOI
Keratocyte and fibroblast phenotypes in the repairing cornea.
TL;DR: Evidence is presented for the view that transition in fibroblast phenotype in repair tissue is not simply a matter of differential gene expression, but is a developmental event which reflects changes in the hard wiring of signalling pathways by which the cell responds to environmental input.