Kinetics of Cytochrome P450 2E1-Catalyzed Oxidation of Ethanol to Acetic Acid via Acetaldehyde
TLDR
Competition experiments suggest that P450 2E1 binds acetic acid and acetaldehyde with relatively high K d values, which preclude simple tight binding as an explanation for rate-limiting product release, and k cat is similar for both reactions, suggesting a possible common catalytic mechanism.About:
This article is published in Journal of Biological Chemistry.The article was published on 1999-08-20 and is currently open access. It has received 127 citations till now. The article focuses on the topics: Acetaldehyde & Acetic acid.read more
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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.
TL;DR: Alkane hydroxylation proceeds by TSR,70-72,120 in which the HS mechanism is truly stepwise with a finite lifetime for the radical intermediate, whereas the LS mechanism is effectively concerted with an ultrashort lifetime forThe radical intermediate.
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Cytochrome P450 and Chemical Toxicology
TL;DR: Crystal structures of several of the major human P450s are now in hand, and unresolved problems include the characterization of the minor "orphan" P 450s, ligand cooperativity and kinetic complexity of several P450S, the prediction of metabolism, the overall contribution of bioactivation to drug idiosyncratic problems, the extrapolation of animal test results to humans in drug development, and the contribution of genetic variation in human P550s to cancer incidence.
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The role of short-chain fatty acids in microbiota-gut-brain communication.
TL;DR: This Review summarizes existing knowledge on the potential of SCFAs to directly or indirectly mediate microbiota–gut–brain interactions and their interaction with gut–brain signalling pathways including immune, endocrine, neural and humoral routes.
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Advanced Organic Chemistry
TL;DR: In this paper, the authors present an overview of the relationship between organic chemistry and natural products, focusing on the Stereochemistry and the Chemistry of Natural Products (SCHP).
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P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations
TL;DR: This work confirms that setup issues can be resolved in a consistent manner if proper care is exercised and generates a common setup that gives QM/MM results for P450cam which are generally consistent with those obtained previously with individual setups.
References
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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
TL;DR: The results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis.
Book
The systematic identification of organic compounds
TL;DR: In this paper, the authors present a survey of the organic chemistry literature, including preliminary examination, physical properties, and elemental analysis, and a classification of organic compounds by solubility.
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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
TL;DR: The results collectively indicate that P-450 IIE1 is a major catalyst of the oxidation of benzene, styrene, CCl4, CHCl3, CH2Cl2, CH3Cl, 1,2-dichloropropane, ethylene dichloride, vinyl chloride, vinyl bromide, acrylonitrile, vinyl carbamate, ethylcarbamate, and trichloroethylene.
BookDOI
Advanced organic chemistry
TL;DR: In this paper, advanced organic chemistry, Advanced organic chemistry (AOC), Advanced organic Chemistry (ACC), Advanced Organic Chemistry (AOG), Advanced OCL, Advanced OCC (ACO),
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Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.
TL;DR: Titration of these purified preparations aerobically with both NADPH and potassium ferricyanide demonstrated unequivocally that the air-stable, reduced form of NADPH-cytochrome c (P-450) reductase contains 2 electron equivalents, confirming recent results obtained.