Journal ArticleDOI
L‐5‐Hydroxytryptophan‐(L‐5‐HTP) Therapie*
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TLDR
Their experience on 107 cases of endogenous depression shows that L‐5‐hydroxy‐tryptophan is clinically effective, and if the authors disregard the cases who showed improvement only after 4 weeks, more than half of the cases improved within a few weeks by L‐ 5‐HTP.Abstract:
Summary
Our experience on 107 cases of endogenous depression shows that L-5-hydroxy-tryptophan is clinically effective If we disregard the cases who showed improvement only after 4 weeks, more than half of the cases improved within a few weeks by L-5-HTP
We propose that endogenous depression is a disease in which biosynthesis of serotonin is periodically decreased, and this decrease is shown clinically as depression, and L-5-HTP, which penetrates into brain through blood brain barrier and is decar-boxylated to form serotonin, may well be supplying serotonin the brain of depression needs
The dose used by us is rather low comparing to L-DOPA dose on parkinsonism, and changes of serotonin or 5-hydroxyindole acetic acid level in blood or cerebrospinal fluid may be very small, although still to be determined
As far as we have experienced, the administration of L-5-HTP for several weeks caused no severe side effects
The administration of L-5-HTP, we believe, opened a new approach to treat and analyse endogenous depression Clinically, it is effective for the treatment and prevention of the depressive phase of endogenous depression An important problem is why the biosynthesis of serotonin is decreased in endogenous depression, and this problem is to be solved to understand the basic disorder of the diseaseread more
Citations
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Journal ArticleDOI
Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan
Erick H. Turner,Erick H. Turner,Jennifer M. Loftis,Jennifer M. Loftis,Aaron D. Blackwell,Aaron D. Blackwell +5 more
TL;DR: Preclinical and clinical evidence for the efficacy of 5-HTP for depression is reviewed, with emphasis on double-blind, placebo-controlled (DB-PC) trials, and safety issues with 5- HTP are reviewed,With emphasis on eosinophilia myalgia syndrome (EMS) and serotonin syndrome.
Journal Article
5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor
TL;DR: Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia.
Journal ArticleDOI
The relationship of serotonin to depression in Parkinson's disease.
TL;DR: The hypothesis that depression in idiopathic Parkinson's disease is associated with a reduction in brain serotonin is supported, but it also suggests that other factors, biological or environmental, may be causal factors.
Book ChapterDOI
Hypersensitive serotonergic receptors: a new hypothesis for one subgroup of unipolar depression derived from an animal model.
M. H. Aprison,J. N. Hingtgen +1 more
TL;DR: This paper expands on a recently proposed theory that associates some forms of human depression with hypersensitive 5-HT receptors after presenting a brief review of some of the pertinent data, mainly from the own studies, which support this theory.
Journal ArticleDOI
Safety of 5-hydroxy-L-tryptophan.
TL;DR: Extensive analyses of several sources of 5-HTP have shown no toxic contaminants similar to those associated with L-Trp, nor the presence of any other significant impurities, which has raised undue speculations concerning its chemistry and toxicity.
References
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Journal ArticleDOI
5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides
TL;DR: The knowledge that loss of amines may be associated with depression, and that their replenishment in the brain may induce recovery, immediately leads to the question as to which of the biogenic amines is responsible for the affective changes.
Journal ArticleDOI
5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases
G. W. Ashcroft,T. B. B. Crawford,D. Eccleston,D.F. Sharman,ElizabethJ. Macdougall,J.B. Stanton,J.K. Binns +6 more
Journal ArticleDOI
Tryptophan in the treatment of depression.
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Journal ArticleDOI
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Journal ArticleDOI
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid.
TL;DR: In suicide victims the cerebral concentration of indoleamines proved to differ from that in a control group and, according to Shaw et al.12, the 5-HT concentrations were diminished, and Bourne etAl.13 were unable to corroborate this but did find a diminished concentration of 5-HIAA.