Journal ArticleDOI
Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation
Muzammil Iqbal,Martin A. Gleeson,Bradley Spaugh,Frank Tybor,William Gunn,Michael Hochberg,Tom Baehr-Jones,Ryan C. Bailey,L. Cary Gunn +8 more
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TLDR
A platform for real-time binding assays on sensor arrays based on silicon ring resonators is presented in this article, where an array of 32 sensors is interrogated simultaneously and 24 simultaneous binding curves are produced.Abstract:
A platform for performing rapid, real-time binding assays on sensor arrays based on silicon ring resonators is presented in this paper. An array of 32 sensors is interrogated simultaneously. Using eight sensors as controls, 24 simultaneous binding curves are produced. The bulk refractive index sensitivity of the system was demonstrated down to 7.6 × 10-7 and sensor-to-sensor variability is 3.9%. Using an 8-min incubation, real-time binding was observed over 8-logs of concentration down to 60 fM using immobilized biotin to capture streptavidin diluted in bovine serum albumin solution. Multiplexing in complex media is demonstrated with two DNA oligonucleotide probes. Time to result and repeatability are demonstrated to be adequate for clinical applications.read more
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Silicon microring resonators
Wim Bogaerts,P. De Heyn,T. Van Vaerenbergh,K. De Vos,S. Kumar Selvaraja,Tom Claes,Pieter Dumon,Peter Bienstman,D. Van Thourhout,Roel Baets +9 more
TL;DR: An overview of the current state-of-the-art in silicon nanophotonic ring resonators is presented in this paper, where the basic theory of ring resonance is discussed and applied to the peculiarities of submicron silicon photonic wire waveguides: the small dimensions and tight bend radii, sensitivity to perturbations and the boundary conditions of the fabrication processes.
Journal ArticleDOI
Integrated optical devices for lab-on-a-chip biosensing applications
TL;DR: This review provides an extended overview of the state-of-the-art in integrated photonic biosensors technology including interferometers, grating couplers, microring resonators, photonic crystals and other novel nanophotonic transducers.
Journal ArticleDOI
Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.
Frank Vollmer,Lan Yang +1 more
TL;DR: In this article, a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection is presented.
Journal ArticleDOI
Hybrid Silicon Photonic Integrated Circuit Technology
Martijn J. R. Heck,Jared F. Bauters,Michael L. Davenport,Jonathan K. Doylend,Siddharth Jain,Geza Kurczveil,Sudharsanan Srinivasan,Yongbo Tang,John E. Bowers +8 more
TL;DR: In this paper, the current status of the hybrid silicon photonic integration platform with emphasis on its prospects for increased integration complexity is reviewed, and it is shown that this platform is well positioned and holds great potential to address future needs for medium-scale photonic integrated circuits.
Book
Silicon Photonics Design: From Devices to Systems
TL;DR: In this article, the authors present the state-of-the-art in the field of fabless silicon photonic systems, including the following: 1.1 Optical Waveguide Mode Solver 2.2 Wave Propagation 2.3 Optoelectronic models 2.4 Microwave Modelling 2.5 Thermal Modeling 2.6 Photonic Circuit Modelling 3.7 Physical Layout 2.8 Software Tools Integration 3.4 Code Listings 4.5 Problems 4.7 Problems 5.4 Polarization 5.5 Problem 5.6 Code List
References
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Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors
TL;DR: The biospecific interaction of the immobilized ligand with its biological counterpart is illustrated by the effects on the interaction of immunoglobulins with immobilized Staphylococcus aureus protein A for various amounts of protein A.
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Label-Free, Single-Molecule Detection with Optical Microcavities
TL;DR: A highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 108) whispering-gallery microcavity is reported and label-free, single-molecule detection of interleukin-2 was demonstrated in serum.
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Universal relations for coupling of optical power between microresonators and dielectric waveguides
TL;DR: In this article, the fundamental working equations required to describe the associated power transfer are derived and the application of this geometry to a variety of optical phenomena including add/dropping of optical beams, add/drop filtering and optical power switching are discussed.
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Silicon-on-Insulator microring resonator for sensitive and label-free biosensing
TL;DR: This work proposes a label-free biosensor based on microring cavities in Silicon-on-Insulator (SOI) that fits in an area below 10x10mum(2), and uses the avidin/biotin high affinity couple to demonstrate good repeatability and detection of protein concentrations down to 10ng/ml.
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Shift of whispering-gallery modes in microspheres by protein adsorption
TL;DR: The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsor adaptation in the most sensitive region varying as 1/R(5/2).