Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases
Jairo Alfonso Mendoza-Roldan,Jan Votýpka,Claudio Bandi,Sara Epis,David Modrý,Lucie Tichá,Petr Volf,Domenico Otranto +7 more
TLDR
The systematics and biology of L. tarentolae in the insect vectors and the vertebrate hosts are discussed and questions about evolution of reptilian leishmaniae are addressed.Abstract:
Abstract Leishmaniasis (or the leishmaniases), classified as a neglected tropical parasitic disease, is found in parts of the tropics, subtropics and southern Europe. Leishmania parasites are transmitted by the bite of phlebotomine sand flies and million cases of human infection occur annually. Leishmania tarentolae has been historically considered a non‐pathogenic protozoan of reptiles, which has been studied mainly for its potential biotechnological applications. However, some strains of L. tarentolae appear to be transiently infective to mammals. In areas where leishmaniasis is endemic, recent molecular diagnostics and serological positivity to L. tarentolae in humans and dogs have spurred interest in the interactions between these mammalian hosts, reptiles and Leishmania infantum, the main aetiologic agent of human and canine leishmaniasis. In this review, we discuss the systematics and biology of L. tarentolae in the insect vectors and the vertebrate hosts and address questions about evolution of reptilian leishmaniae. Furthermore, we discuss the possible usefulness of L. tarentolae for new vaccination strategies.read more
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Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases
Jairo Alfonso Mendoza-Roldan,Jan Votýpka,Claudio Bandi,Sara Epis,David Modrý,Lucie Tichá,Petr Volf,Domenico Otranto +7 more
TL;DR: The systematics and biology of L. tarentolae in the insect vectors and the vertebrate hosts are discussed and questions about evolution of reptilian leishmaniae are addressed.
Journal ArticleDOI
Leishmaniasis.
Gad Baneth,Laia Solano-Gallego +1 more
TL;DR: Leishmaniasis caused by Leishmania infantum is an important zoonotic disease transmitted by sand flies with a high prevalence of infection in dogs and cats in regions whereby transmission occurs as mentioned in this paper .
Journal ArticleDOI
Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19
Sara Epis,Ilaria Varotto-Boccazzi,Alessandro Manenti,Diego Rubolini,Paolo Gabrielli,Giulia Cattaneo,Louise J. Gourlay,Francesca Dapporto,Martina Monti,Ilaria Razzano,Margherita Leonardi,Matteo Iannacone,Camilla Recordati,Luca Bertola,Paolo Fiorina,Luigi Marvasi,Emanuele Montomoli,Gian Vincenzo Zuccotti,Claudio Bandi +18 more
TL;DR: In this paper , the authors proposed Leishmania tarentolae, a protozoan parasite, as a potential antigen vehicle for mucosal vaccination, for administration via the rectal or oral routes.
Journal ArticleDOI
Immunisation with Transgenic L. tarentolae Expressing Gamma Glutamyl Cysteine Synthetase from Pathogenic Leishmania Species Protected against L. major and L. donovani Infection in a Murine Model
TL;DR: In this paper , transgenic Leishmania tarentolae expressing gamma glutamyl cysteine synthetase (γGCS) from three pathogenic species were produced and their ability to protect against infection determined using models of cutaneous and visceral leishmaniasis.
Journal ArticleDOI
Intracellular persistence of Leishmania tarentolae in primary canine macrophage cells.
Viviane Noll Louzada-Flores,Maria Stefania Latrofa,Maria Stella Lucente,Bibiana Paula Dambrós,Jairo Alfonso Mendoza-Roldan,Ilaria Varotto-Boccazzi,Gerald F. Späth,Alessio Buonavoglia,Domenico Otranto +8 more
TL;DR: In this article , the authors evaluated the ability of Leishmania tarentolae to colonize, survive and persist in primary monocyte-derived mononuclear cells in dogs.
References
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Journal ArticleDOI
A Historical Overview of the Classification, Evolution, and Dispersion of Leishmania Parasites and Sandflies
Mohammad Akhoundi,Katrin Kuhls,Arnaud Cannet,Jan Votýpka,Pierre Marty,Pascal Delaunay,Denis Sereno +6 more
TL;DR: An updated view of events that have played important roles in the geographical dispersion of sandflies, in relation to both the Leishmania species they transmit and the animal reservoirs of the parasites is proposed.
Journal ArticleDOI
Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern
TL;DR: The roles of phlebotomines in the spreading of leishmaniases, sandfly fever, summer meningitis, vesicular stomatitis, Chandipura virus encephalitis and Carrión's disease are reviewed.
Journal ArticleDOI
A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited information.
TL;DR: In this paper, a model is presented in which a partial hybrid formed between the gRNA and pre-edited mRNA is substrate for multiple cycles of cleavage, addition or deletion of uridylates, and religation, eventually resulting in a complete hybrid between the guide RNA and the mature edited mRNA.
Journal ArticleDOI
Biology of the Kinetoplastida
W. H. R. Lumsden,D. A. Evans +1 more
TL;DR: Throughout the bookributors point out new approaches to the study of these organisms, e.g., in their morphology and physiology and in the complexities of the hosts' responses to invasion.
Journal ArticleDOI
Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
TL;DR: The current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed, and the most important mechanism is the creation of a “blocked fly” resulting from the secretion of promastigote secretory gel by the parasites in the anterior midgut.
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