Open AccessJournal Article
Leukocytes of normal pregnant women.
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This article is published in Obstetrics & Gynecology.The article was published on 1964-03-01 and is currently open access. It has received 63 citations till now. The article focuses on the topics: Hemoglobinometry & Alkaline phosphatase.read more
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Maternal urinary tract infection: is it independently associated with adverse pregnancy outcome?
TL;DR: Maternal UTI is independently associated with pre-term delivery, pre-eclampsia, IUGR and CD, Nevertheless, it is not associated with increased rates of perinatal mortality compared with women without UTI.
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Phenotypic and metabolic characteristics of monocytes and granulocytes in normal pregnancy and maternal infection
Nihal Naccasha,Maria-Teresa Gervasi,Tinnakorn Chaiworapongsa,Susan Berman,Bo Hyun Yoon,Eli Maymon,Roberto Romero +6 more
TL;DR: Qualitative differences indicate that the innate limb of the immune response is not maximally activated during normal pregnancy, and pregnant women with acute infection had more marked phenotypic and metabolic changes of leukocytes than normal pregnant women.
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Normal pregnancy is characterized by systemic activation of the complement system
Karina Richani,Eleazar Soto,Roberto Romero,Jimmy Espinoza,Tinnakorn Chaiworapongsa,Jyh Kae Nien,Samuel Edwin,Yeon Mee Kim,Joon Seok Hong,Moshe Mazor +9 more
TL;DR: It is proposed that physiologic activation of the complement system during pregnancy is a compensatory mechanism aimed at protecting the host against infection.
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Could an infectious trigger explain the differential maternal response to the shared placental pathology of preeclampsia and normotensive intrauterine growth restriction
TL;DR: The evidence for an infectious trigger is principally indirect, linking the similarities between acute atherosis in preeclampsia and atherosclerosis, the increased likelihood of developing cardiovascular disease later in life following a preeclamping pregnancy, and the association between chronic infection and atherogenesis.
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Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo.
Kevin J. Kauffman,Faryal F. Mir,Siddharth Jhunjhunwala,James C. Kaczmarek,Juan E. Hurtado,Jung H. Yang,Matthew J. Webber,Piotr S. Kowalski,Michael W. Heartlein,Frank Derosa,Daniel G. Anderson +10 more
TL;DR: Insight is provided into the immune responses to lipid nanoparticle-formulated unmodified and pseudouridine-modified mRNAs administered systemically in vivo, and it is suggested that pseudouredidine modifications may be unnecessary for therapeutic application of mRNA in the liver.