Journal ArticleDOI
Lidocaine and surgical modification reduces mortality in a rat model of cardiac failure induced by coronary artery ligation.
Andrew R Kompa,Roger J. Summers +1 more
TLDR
It is found that coronary artery ligation, using lidocaine in conjunction with a modified surgical procedure, had a mortality rate of 15%, much lower than reported in previous studies using this model.About:
This article is published in Journal of Pharmacological and Toxicological Methods.The article was published on 2000-05-01. It has received 29 citations till now. The article focuses on the topics: Myocardial infarction & Sudden death.read more
Citations
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Journal ArticleDOI
Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): Effect of pertussis toxin
TL;DR: Cardiac failure in MI animals caused a reduced inotropic response to both relaxin and (−)‐isoprenaline, and in non‐MI animals, PTX treatment significantly reduced relaxin‐, isoprenalin‐ and forskolin‐stimulated cAMP accumulation.
Journal ArticleDOI
Rat models of myocardial infarction. Pathogenetic insights and clinical relevance
TL;DR: The following discussion reviews and examines the current rat models of AMI, places them in a clinical context, discusses their advantages and limitations, and outlines likely future developments, providing an overview of the place of these important models.
Journal ArticleDOI
Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction.
Andrew R Kompa,Fiona See,Dion Lewis,Anastasia Adrahtas,Danielle Cantwell,Bing Hui Wang,Henry Krum +6 more
TL;DR: Continuous but not short-term p38 MAPK blockade attenuates post-MI remodeling, which is associated with functional benefits on the myocardium, and in vitro experiments confirmed a dose-dependent reduction in hypertrophy, with RWJ following tumor necrosis factor-α stimulation.
Journal ArticleDOI
Cardioprotective effects of salidroside on myocardial ischemia-reperfusion injury in coronary artery occlusion-induced rats and Langendorff-perfused rat hearts.
Xiayun Chang,Kai Zhang,Rui Zhou,Fen Luo,Lingpeng Zhu,Jin Gao,He He,Tingting Wei,Tianhua Yan,Chunhua Ma +9 more
TL;DR: The present study comprehensively elaborated the protective effects of salidroside on myocardial injury and demonstrated that AM PK/PGC-1α and AMPK/NF-κB signaling cascades were implicated in the myocardia-reperfusion injury (I/R) model.
Journal ArticleDOI
Direct detection of myocardial fibrosis by MRI
Sanne de Jong,Jaco J.M. Zwanenburg,Fredy Visser,Fredy Visser,Roel van der Nagel,Harold V.M. van Rijen,Marc A. Vos,Jacques M.T. de Bakker,Peter R. Luijten +8 more
TL;DR: It is shown for the first time that UTE MRI technology can be used for direct detection of post-infarcted fibrosis without the use of contrast agents.
References
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Journal ArticleDOI
Myocardial infarct size and ventricular function in rats.
Marc A. Pfeffer,Janice M. Pfeffer,Michael C. Fishbein,P J Fletcher,J Spadaro,Robert A. Kloner,Eugene Braunwald +6 more
TL;DR: In this model of histologically healed myocardial infarction, the impairment of left ventricular function was directly related to the loss of myocardium, and the entire spectrum of postinfarction ventricularfunction was observed, from no detectable impairment to congestive failure.
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Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.
TL;DR: An impairment of cardiac performance correlated with the infarct size-related increase in diastolic volume, which served to offset the reduction in flow generating capacity caused by systolic dysfunction, while contributing directly to the impairment of pressure generating capacity.
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Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth.
TL;DR: It is demonstrated that cardiac hypertrophy following myocardial infarction is consistent with cellular shape changes characteristic of a combination of concentric and eccentric hypertrophic growth, however, cardiac muscle cells appear to be unable to compensate for the loss of mass induced by a 50% infarct.
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Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size
TL;DR: The model, because of its simplicity, reproducibility, and low cost, should be useful for the screening of potential antidysrhythmic agents and may also be used to determine infarct size following coronary artery ligation.
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Intramuscular lidocaine for prevention of lethal arrhythmias in the prehospitalization phase of acute myocardial infarction.
TL;DR: It is concluded that intramuscular lidocaine may be useful if given by a paramedic, another person, or the patient himself when acute myocardial infarction is suspected outside the hospital.