Journal ArticleDOI
Lipophilicity of a series of 1,2-benzisothiazol-3(2H)-ones determined by reversed-phase thin-layer chromatography
Tomasz Sławik,Cezary Kowalski +1 more
TLDR
The lipophilicity (R(Mo)) and specific hydrophobic surface area of seven 1,2-benzisothiazol-3(2H)-ones have been determined by reversed-phase TLC and the effect of different mobile-phase modifiers on the retention has been studied.About:
This article is published in Journal of Chromatography A.The article was published on 2002-04-05. It has received 28 citations till now. The article focuses on the topics: Reversed-phase chromatography & Lipophilicity.read more
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Patent
Pyrrole and pyrazole daao inhibitors
TL;DR: In this paper, D-serine or cycloserine may be coadministered along with a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain.
Journal ArticleDOI
Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography.
TL;DR: Conclusions on structure-lipophilicity relationships were drawn in terms of ring anellation, character and length of side chain, conformational preferences and moiety-solvent interactions, also supported by molecular mechanics studies.
Patent
Benzo[d]isoxazol-3-ol DAAO inhibitors
TL;DR: In this article, the authors present methods for increasing D-Serine concentration and reducing concentration of the toxic products of DSerine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases.
Patent
Cycloalkylamines as monoamine reuptake inhibitors
Liming Shao,Fengjiang Wang,Scott Christopher Malcolm,Michael C. Hewitt,Larry R. Bush,Jianguo Ma,Mark A. Varney,Una Campbell,Sharon Rae Engel,Larry W. Hardy,Patrick Koch,John Emmerson Campbell +11 more
TL;DR: The cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis were discussed in this paper.
Journal ArticleDOI
Lipophilicity of novel antitumour and analgesic active 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione derivatives determined by reversed-phase HPLC and computational methods
TL;DR: The lipophilicity variation of investigated imidazotriazine-3,4-diones (1-8) correlates well with their acute toxicity expressed as log(1/LD50).
References
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Journal ArticleDOI
A New Substituent Constant, π, Derived from Partition Coefficients
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"Aromatic" substituent constants for structure-activity correlations
Journal ArticleDOI
Linear Relationships between Lipophilic Character and Biological Activity of Drugs
Corwin Hansch,William J. Dunn +1 more
TL;DR: Chloroacetaldehyde, a probable metabolite of 2-chlorc- ethanol (ethylene chlorohydrin), was studied in a number of animal systems, in in oitro hemolysis tests, and in tissue cultures to obtain a toxicity profile of the compound.
Journal ArticleDOI
Partition data of penicillins determined by means of reversed-phase thin-layer chromatography.
TL;DR: RM values were calculated by interpolation or extrapolation from the ranges of linearity between RM values and composition of the mobile phase and the influence of substituent groups on the RM values of the penicillins.