Journal ArticleDOI
Liquid-core optical ring-resonator sensors
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TLDR
The LCORR takes advantage of the high sensitivity, small footprint, and low sample consumption with the ring resonator, as well as the efficient fluidic sample delivery with the capillary, and will open an avenue to future multiplexed sensor array development.Abstract:
We have demonstrated a novel sensor architecture based on a liquid-core optical ring-resonator (LCORR) in which a fused silica capillary is utilized to carry the aqueous sample and to act as the ring resonator. The wall thickness of the LCORR is controlled to a few micrometers to expose the whispering gallery mode to the aqueous core. Optical characterization with a water-ethanol mixture shows that the spectral sensitivity of the LCORR sensor is approximately 2.6 nm per refractive index unit. A model based on Mie theory is established to explain the experimental results. The LCORR takes advantage of the high sensitivity, small footprint, and low sample consumption with the ring resonator, as well as the efficient fluidic sample delivery with the capillary, and will open an avenue to future multiplexed sensor array development.read more
Citations
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Journal ArticleDOI
Sensitive optical biosensors for unlabeled targets: a review.
TL;DR: This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms, and focuses on the optical biosENSors that utilize the refractive index change as the sensing transduction signal.
Journal ArticleDOI
On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh- Q microresonator
Jiangang Zhu,Sahin Kaya Ozdemir,Yun-Feng Xiao,Yun-Feng Xiao,Lin Li,Lina He,Da-Ren Chen,Lan Yang +7 more
TL;DR: In this article, the authors report real-time detection and sizing of single nanoparticles, down to 30 nm in radius, using mode splitting in a monolithic ultrahigh-quality-factor (Q) whispering-gallery-mode microresonator.
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Optofluidic microsystems for chemical and biological analysis
Xudong Fan,Ian M. White +1 more
TL;DR: The mechanisms by which optofluidics enhances bio/chemical analysis capabilities, including sensing and the precise control of biological micro/nanoparticles, are emphasized.
Journal ArticleDOI
Whispering gallery microcavity lasers
TL;DR: In this article, the progress in WGM microcavity lasers is summarized, and the laser performance considering resonator geometries and materials as well as lasing mechanisms is discussed.
Journal ArticleDOI
Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.
Frank Vollmer,Lan Yang +1 more
TL;DR: In this article, a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection is presented.
References
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Book
Absorption and Scattering of Light by Small Particles
TL;DR: In this paper, a Potpourri of Particles is used to describe surface modes in small Particles and the Angular Dependence of Scattering is shown to be a function of the size of the particles.
Journal ArticleDOI
Ultimate Q of optical microsphere resonators.
TL;DR: It is demonstrated that quality factor Q - (0.8 +/- 0.1) x 10(10) of whispering-gallery modes in fused-silica microspheres at 633 nm, close to the ultimate level determined by fundamental material attenuation as measured in optical fibers, is demonstrated.
Journal ArticleDOI
Protein detection by optical shift of a resonant microcavity
TL;DR: In this article, an optical biosensor with unprecedented sensitivity for detection of unlabeled molecules is presented. But the method relies on the use of a dielectric microparticle (whispering gallery modes) as the physical transducing mechanism.
Journal ArticleDOI
Refractometric sensors based on microsphere resonators
TL;DR: In this paper, the spectral position of the whispering gallery mode (WGM) of a sphere shifts in response to the refractive index change in the surrounding medium, resulting in a sensitivity of approximately 30nm∕RIU (refractive index units).
Journal ArticleDOI
Multiplexed DNA quantification by spectroscopic shift of two microsphere cavities.
TL;DR: It is demonstrated that an optical resonance (whispering gallery mode) excited in a micron-sized silica sphere can be used to detect and measure nucleic acids and each microsphere can be identified by its unique resonance wavelength.
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