Journal ArticleDOI
Whispering-gallery-mode biosensing: label-free detection down to single molecules
Frank Vollmer,Stephen Arnold +1 more
TLDR
The enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor are described, its current implementations and applications are reviewed, and its future possibilities are discussed.Abstract:
Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.read more
Citations
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Journal ArticleDOI
On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh- Q microresonator
Jiangang Zhu,Sahin Kaya Ozdemir,Yun-Feng Xiao,Yun-Feng Xiao,Lin Li,Lina He,Da-Ren Chen,Lan Yang +7 more
TL;DR: In this article, the authors report real-time detection and sizing of single nanoparticles, down to 30 nm in radius, using mode splitting in a monolithic ultrahigh-quality-factor (Q) whispering-gallery-mode microresonator.
Journal ArticleDOI
Loss-induced suppression and revival of lasing.
Bo Peng,Sahin Kaya Ozdemir,Stefan Rotter,Huzeyfe Yilmaz,Matthias Liertzer,Faraz Monifi,Carl M. Bender,Franco Nori,Lan Yang +8 more
TL;DR: Overturning conventional wisdom that loss is bad and should be minimized, Peng et al. show that carefully tweaking the coupling strength between the various components of a coupled optical system can actually result in an enhancement of the optical properties by adding more loss into the system.
Journal ArticleDOI
Whispering gallery mode sensors
TL;DR: A comprehensive overview of sensor technology exploiting optical whispering gallery mode (WGM) resonances by detailing the fundamental principles and theory of WGMs in optical microcavities and the transduction mechanisms frequently employed for sensing purposes.
Journal ArticleDOI
Single virus detection from the reactive shift of a whispering-gallery mode.
TL;DR: The label-free, real-time optical detection of Influenza A virus particles is reported and a reactive sensing mechanism with inverse dependence on mode volume is confirmed in experiments with virus-sized polystyrene nanoparticles.
Journal ArticleDOI
Detecting single viruses and nanoparticles using whispering gallery microlasers.
TL;DR: A whispering gallery mode microlaser-based real-time and label-free detection method that can detect individual 15-nm-radius polystyrene nanoparticles, 10-nm gold nanoparticles and influenza A virions in air, and 30 nm polystyren nanoparticles in water.
References
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J.C. McDonald,David C. Duffy,Janelle R. Anderson,Daniel T. Chiu,Hongkai Wu,Olivier Schueller,George M. Whitesides +6 more
TL;DR: Fabrication of microfluidic devices in poly(dimethylsiloxane) (PDMS) by soft lithography provides faster, less expensive routes to devices that handle aqueous solutions.
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Mimicking photosynthetic solar energy transduction
TL;DR: The overall energy transduction process in the liposomal system mimics the solar energy conversion system of a photosynthetic bacterium and illustrates the advantages of designing functional nanoscale devices based on biological paradigms.
Journal ArticleDOI
Label-Free, Single-Molecule Detection with Optical Microcavities
TL;DR: A highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 108) whispering-gallery microcavity is reported and label-free, single-molecule detection of interleukin-2 was demonstrated in serum.
Journal ArticleDOI
Protein detection by optical shift of a resonant microcavity
TL;DR: In this article, an optical biosensor with unprecedented sensitivity for detection of unlabeled molecules is presented. But the method relies on the use of a dielectric microparticle (whispering gallery modes) as the physical transducing mechanism.
Journal ArticleDOI
Phase-matched excitation of whispering-gallery-mode resonances by a fiber taper
TL;DR: It is shown that high-Q whispering-gallery modes in fused-silica microspheres can be efficiently excited by an optical fiber taper and is believed to be the most efficient excitation of a high- Q microcavity resonance by a monomode optical fiber yet demonstrated.