Local Regulation of Vascular Cross Section during Changes in Femoral Arterial Blood Flow in Dogs
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The dilatation response occurred despite slight reductions in femoral blood pressure, and was present after ganglionic blockade, blockade of alpha and beta receptors with phenoxybenzamine and propranolol, atropinization and injection of an antihistamine.Abstract:
Diameters of the exposed femoral artery of anesthetized dogs were continuously measured with ultrasonic elements of lead zirconate titanate. In 13 of 16 dogs vascular diameters increased following a sudden increment in arterial blood flow induced by the injection of vasodilating agents (acetylcholine, histamine) peripheral to the recording level, by opening an arteriovenous shunt, or after tetanic stimulation of the sciatic nerve. The dilatation response occurred despite slight reductions in femoral blood pressure, and was present after ganglionic blockade, blockade of alpha and beta receptors with phenoxybenzamine and propranolol, atropinization and injection of an antihistamine. The dilatation response was also observed after transsection of the femoral artery distal to the recording level and is therefore not dependent on the retrograde propagation of nervous or myogenous impulses along the vascular wall.read more
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Dissertation
Endothelial dysfunction in atherosclerosis.
TL;DR: A novel model for assessing the effect of ischaemia-reperfusion on endothelial function was developed and indicated that 20 minutes of forearm ischaemic caused endothelial dysfunction and activated circulating neutrophils, which implicate acute inflammation as a possible mechanism of endotocyte dysfunction in humans and a link between inflammation and acute cardiovascular risk.
Journal ArticleDOI
The effect of pressure drop stabilization in arteries during variations in blood flow rate.
TL;DR: The aim of this study was to clear up whether the flow-induced dilation of arteries is sufficient to ensure invariability of pressure drop along these vessels under many-fold increase in blood flow rate, and in anaesthetized rats an arteriovenous shunt was constructed by connecting the saphenous artery and the femoral vein.
Piezo1: Proteins for mechanotransduction and integration of endothelial shear stress & intravascular pressure
TL;DR: ............................................................................................................................... i Acknowledgments.............................................................................................................. ii Table of
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Flow-diameter phase shift: A potential indicator of conduit artery function
Daniel Hayoz,Luciano Bernardi,Georg Noll,Roger Weber,Claude-A. Porret,Claudio Passino,René R. Wenzel,Nikos Stergiopulos +7 more
TL;DR: The results suggest that the very-low-frequency vasomotion pattern in this conduit vessel might be a flow- or shear stress-dependent phenomenon and offer a new way of addressing vascular wall function in medium-sized and large arteries in subjects with cardiovascular risk factors.
Book ChapterDOI
Role of EDRF/NO in Chronic High Coronary Blood Flow States During Myocardial Dysfunction and Failure
TL;DR: The emphasis on the contractile failure of the myocardium as the progenitor of heart failure is underscored.
References
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Journal ArticleDOI
The Pharmacological Basis of Therapeutics
TL;DR: The Pharmacological Basis of Therapeutics, by Prof. Louis Goodman and Prof. Alfred Gilman, New York: The Macmillan Company, 1941, p.
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On the local reactions of the arterial wall to changes of internal pressure.
TL;DR: My attention was first directed to these phenomena by the occurrence of curves like that reproduced in Fig. 11, which showed the effect of a fall of arterial pressure produced by exI citing the central end of the depressor nerve on the volume of the hind leg of the rabbit, the sciatic and the nerves accompanying the femoral artery having been cut.