Local Regulation of Vascular Cross Section during Changes in Femoral Arterial Blood Flow in Dogs
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TLDR
The dilatation response occurred despite slight reductions in femoral blood pressure, and was present after ganglionic blockade, blockade of alpha and beta receptors with phenoxybenzamine and propranolol, atropinization and injection of an antihistamine.Abstract:
Diameters of the exposed femoral artery of anesthetized dogs were continuously measured with ultrasonic elements of lead zirconate titanate. In 13 of 16 dogs vascular diameters increased following a sudden increment in arterial blood flow induced by the injection of vasodilating agents (acetylcholine, histamine) peripheral to the recording level, by opening an arteriovenous shunt, or after tetanic stimulation of the sciatic nerve. The dilatation response occurred despite slight reductions in femoral blood pressure, and was present after ganglionic blockade, blockade of alpha and beta receptors with phenoxybenzamine and propranolol, atropinization and injection of an antihistamine. The dilatation response was also observed after transsection of the femoral artery distal to the recording level and is therefore not dependent on the retrograde propagation of nervous or myogenous impulses along the vascular wall.read more
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Book ChapterDOI
Endothelium, Blood Flow, and Vascular Responses in Large Coronary and Iliac Arteries of the Conscious Dog
M. A. Young,Stephen F. Vatner +1 more
TL;DR: The laboratory and several others have examined the question of endothelium-mediated responses in vivo, studying large arteries to the hindlimb and to the heart, finding that the metabolic requirements of the hind Limb do not dramatically affect the responsiveness of the large vessel, as is the case in the coronary circulation.
Intraluminal FlowIncreases Vascular Toneand 45Ca2' Influx intheRabbit Facial Vein
Daniel Henrion,Ismail Laher +1 more
TL;DR: Weconclude thatflow-induced contraction intherabbit facial veinisassociated with Ca2'entry intothesmoothmuscle cells through a pathway that may bedifferent from thatassociated withstretch-activated contraction.
Dissertation
Noninvasive ultrasound techniques for assessment of early atherosclerosis
TL;DR: It is concluded that measurement of vasoreactivity, IMT, and distensibility with this measurement system provides insight to arterial health and may lead to noninvasive assessment of early atherosclerosis and of therapeutic efficacy in individual subjects.
Journal ArticleDOI
Pressure drop stabilization in conducting arteries in response to increased blood flow in rats
TL;DR: Results indicate a significantly greater degree of dilatation of the main arteries of cats and dogs in response to an increase in blood flow and, consequently, that this response could considerably reduce the increase in pressure drop.
References
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Journal ArticleDOI
The Pharmacological Basis of Therapeutics
TL;DR: The Pharmacological Basis of Therapeutics, by Prof. Louis Goodman and Prof. Alfred Gilman, New York: The Macmillan Company, 1941, p.
Journal ArticleDOI
On the local reactions of the arterial wall to changes of internal pressure.
TL;DR: My attention was first directed to these phenomena by the occurrence of curves like that reproduced in Fig. 11, which showed the effect of a fall of arterial pressure produced by exI citing the central end of the depressor nerve on the volume of the hind leg of the rabbit, the sciatic and the nerves accompanying the femoral artery having been cut.