Local Regulation of Vascular Cross Section during Changes in Femoral Arterial Blood Flow in Dogs
Reads0
Chats0
TLDR
The dilatation response occurred despite slight reductions in femoral blood pressure, and was present after ganglionic blockade, blockade of alpha and beta receptors with phenoxybenzamine and propranolol, atropinization and injection of an antihistamine.Abstract:
Diameters of the exposed femoral artery of anesthetized dogs were continuously measured with ultrasonic elements of lead zirconate titanate. In 13 of 16 dogs vascular diameters increased following a sudden increment in arterial blood flow induced by the injection of vasodilating agents (acetylcholine, histamine) peripheral to the recording level, by opening an arteriovenous shunt, or after tetanic stimulation of the sciatic nerve. The dilatation response occurred despite slight reductions in femoral blood pressure, and was present after ganglionic blockade, blockade of alpha and beta receptors with phenoxybenzamine and propranolol, atropinization and injection of an antihistamine. The dilatation response was also observed after transsection of the femoral artery distal to the recording level and is therefore not dependent on the retrograde propagation of nervous or myogenous impulses along the vascular wall.read more
Citations
More filters
Journal ArticleDOI
Local nervous mechanism in regulation of blood flow in human subcutaneous tissue.
TL;DR: The vasoconstrictor impulse elicited during venous stasis is therefore most likely transmitted by means of a local nervous mechanism involving sympathetic adrenergic vasoconStrictor fibres.
Journal ArticleDOI
Effects of short-term forearm exercise training on resistance vessel endothelial function in normal subjects and patients with heart failure***
TL;DR: Forearm exercise training improves endothelium-dependent vasodilation and peak hyperemic FBF in control subjects but not in patients with heart failure, suggesting that resistance vessel abnormalities may not be as readily modifiable by exercise training in patientswith heart failure compared with control subjects.
Journal ArticleDOI
Shear stress regulation of nitric oxide production in uterine and placental artery endothelial cells: experimental studies and hemodynamic models of shear stresses on endothelial cells
TL;DR: Hemodynamic shear stress is the most powerful physiological regulator of endothelial Nitric Oxide Synthase, leading to rapid rises in nitric oxide (NO) production in uterine and placental vascular physiology during gestation, and hemodynamics as they apply to blood flow in vessels is discussed.
Book
The Ocular Circulation
TL;DR: The unique anatomy and physiology of the vascular beds that serve the eye are described, which provide an unobstructed light path from the cornea to the retina and a relatively fixed corneal curvature and distance between refractive structures.
Journal ArticleDOI
The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches
TL;DR: This review presents an overview of endothelial mechanobiology and its relation to the pathogenesis of Atherosclerosis with special reference to the anatomy of the artery and the underlying fluid mechanics, followed by a discussion of a variety of experimental models to study the role of fluid mechanics and atherosclerosis.
References
More filters
Journal ArticleDOI
The Pharmacological Basis of Therapeutics
TL;DR: The Pharmacological Basis of Therapeutics, by Prof. Louis Goodman and Prof. Alfred Gilman, New York: The Macmillan Company, 1941, p.
Journal ArticleDOI
On the local reactions of the arterial wall to changes of internal pressure.
TL;DR: My attention was first directed to these phenomena by the occurrence of curves like that reproduced in Fig. 11, which showed the effect of a fall of arterial pressure produced by exI citing the central end of the depressor nerve on the volume of the hind leg of the rabbit, the sciatic and the nerves accompanying the femoral artery having been cut.