Journal ArticleDOI
Localization of Carbon–Carbon Double Bond and Cyclopropane Sites in Cardiolipins via Gas-Phase Charge Inversion Reactions
TLDR
In this article, a charge inversion ion/ion chemistry in the gas phase was applied to the de novo elucidation of unknown cardiolipins in a biological extract revealing distinct isomeric populations and regiochemical relationships between double bonds and carbocyles.About:
This article is published in Journal of the American Society for Mass Spectrometry.The article was published on 2021-02-03. It has received 16 citations till now. The article focuses on the topics: Cyclopropane & Double bond.read more
Citations
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Journal ArticleDOI
Advanced tandem mass spectrometry in metabolomics and lipidomics-methods and applications.
TL;DR: Tandem mass spectrometry (MS) is the method of choice to unveil structural details of metabolites and lipids as discussed by the authors, but collision-induced dissociation (CID) fragment ions are often not sufficient to fully characterize analytes.
Journal ArticleDOI
Localization of Intrachain Modifications in Bacterial Lipids Via Radical-Directed Dissociation.
TL;DR: A radical-directed dissociation (RDD) approach for characterization of the intrachain modifications within phosphoethanolamines (PEs), a major lipid component in bacterial membrane is reported.
Journal ArticleDOI
Simultaneous Differentiation of C═C Position Isomerism in Fatty Acids through Ion Mobility and Theoretical Calculations.
TL;DR: In this paper , a simple and rapid strategy combining ion mobility spectrometry and theoretical chemical calculations was developed to differentiate and quantify the C═C positional isomers in 2-3-butenoic acid (BA), 2-/3-/4-pentenoic acids (PA), and 2-4-/5-hexenoic alcohol (HA).
Journal ArticleDOI
High-confidence structural identification of metabolites relying on tandem mass spectrometry through isomeric identification: A tutorial
TL;DR: In this article , the authors discuss the developments of cutting-edge techniques concerning differentiation and identification of isomers, including ion mobility spectrometry, ion transport, ion dissociation, and energy-resolved MS.
Journal ArticleDOI
In-silico-library-based method enables rapid and comprehensive annotation of cardiolipins and cardiolipin oxidation products using high resolution tandem mass spectrometer.
Yu He,Binghuan Yuan,Yao Lu,Xia Zhao,Cunsi Shen,Jianjian Ji,Lili Lin,Jianya Xu,Tong Xie,Jinjun Shan +9 more
TL;DR: The proposed in-silico database provides a more comprehensive interpretation for CL species' characterization with high throughput and sensitivity in nontarget lipidomic study and application to murine mitochondria and cell samples enabled the sensitive and comprehensive annotation.
References
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Journal ArticleDOI
Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
Xianlin Han,Richard W. Gross +1 more
TL;DR: This review will focus on the advances in ESI/MS, which have facilitated the development of shotgun lipidomics and the utility of intrasource separation as an enabling strategy for utilization of 2D mass spectrometry in Shotgun lipidomics of biological samples.
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Electrospray mass spectrometry of phospholipids
TL;DR: The current level of understanding of the mechanisms involved in the formation of various product ions following collisional activation of molecular ion species generated by electrospray ionization of the common glycerophospholipids is presented.
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Shorthand notation for lipid structures derived from mass spectrometry
Gerhard Liebisch,Juan Antonio Vizcaíno,Harald Köfeler,Martin Trötzmüller,William J. Griffiths,Gerd Schmitz,Friedrich Spener,Michael J.O. Wakelam +7 more
TL;DR: This defined shorthand nomenclature provides a standard methodology for reporting lipid species from mass spectrometric analysis and for constructing databases and is based on common, officially accepted terms.
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Role of cardiolipin alterations in mitochondrial dysfunction and disease
TL;DR: Evidence that has linked changes in the CL profile to mitochondrial dysfunction in various pathological conditions is provided to provide an overview of evidence.
Journal ArticleDOI
Cardiolipin, the heart of mitochondrial metabolism.
TL;DR: An overview of cardiolipin metabolism, function and its role in different pathological states is provided.