Open AccessJournal Article
Long-term follow-up of Skylab bone demineralization.
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TLDR
A statistically significant loss of bone mineral was found in the crew members who flew, but caution is urged in the interpretation of this difference.Abstract:
The os calcis mineral was measured in the nine Skylab crew members and in eight control subjects, 5 years after the Skylab Program, utilizing a photon absorptiometric technique. These measurements were compared with preflight measurements in an attempt to discover any long-term effects of space flight on the skeletal system. A statistically significant loss of bone mineral was found in the crew members who flew, but caution is urged in the interpretation of this difference. A recommendation to continue studies of this type is made.read more
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Changes in musculoskeletal structure and function with prolonged bed rest.
TL;DR: A review of the various models used by researchers to study disuse-induced changes in muscle and bone as observed during prolonged bed rest in humans is presented in this paper, showing that most of the lost muscle mass and strength can be regained with appropriate resistance training within several weeks after a period of disuse.
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Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling
TL;DR: Recent investigations have extended to the immediate effects of dynamic strains on the structure of the bone matrix, and the biochemical behaviour of the resident bone cells, to reveal the mechanism by which strains within the matrix are transduced into the biochemical signals by which adaptive remodelling is controlled.
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Functional strain as a determinant for bone remodeling
TL;DR: The remodeling responses following a variety of experimental alterations in bones' strain environment are presented, and a scheme for the interaction of mechanical and hormonal influences proposed.
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Longitudinal study of bone mineral content in the lumbar spine, the forearm and the lower extremities after spinal cord injury.
TL;DR: Bone mineral content (BMC) of the lumbar spine, femoral neck and shaft, and proximal tibia was measured by dual photon absorptiometry in six men and two women after traumatic spinal cord injuries and it seems that a steady‐state was not reached within the observation period for several of the patients.
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Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
Janet L. Crane,Xu Cao +1 more
TL;DR: Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.