Journal ArticleDOI
Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes.
TLDR
Microfracture when applied in young patients with smaller lesions can offer good clinical results at short- and long-term follow-up; lesion size is more important prognostic factor of outcome than age.Abstract:
Purpose
Microfracture is a well-established treatment procedure for chondral defects in high-demand population with good short-term results. The purpose of our study was to evaluate long-term clinical outcome of microfracture treatment in athletes with full-thickness chondral defects.read more
Citations
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Journal ArticleDOI
Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.
TL;DR: By understanding the design and production processes of these emerging technologies, one can gain tremendous insight into how to best use them and also how to design the next generation of tissue engineered cartilage products.
Journal ArticleDOI
Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits
Yingying Du,Haoming Liu,Qin Yang,Shuai Wang,Jianglin Wang,Jun Ma,Insup Noh,Antonios G. Mikos,Shengmin Zhang +8 more
TL;DR: This study not only achieves osteochondral repair, but also suggests a promising strategy for the fabrication of bio-inspired multilayer scaffolds with well-designed architecture and gradient composition via SLS technique.
Journal ArticleDOI
A Randomized Multicenter Trial Comparing Autologous Chondrocyte Implantation with Microfracture: Long-Term Follow-up at 14 to 15 Years.
Gunnar Knutsen,Jon Olav Drogset,Lars Engebretsen,Torbjørn Grøntvedt,Tom C. Ludvigsen,Sverre Løken,Eirik Solheim,Torbjørn Strand,Oddmund Johansen +8 more
TL;DR: The findings raise serious concerns regarding the efficacy of autologous chondrocyte implantation and microfracture in patients with focal femoral cartilage injuries in delaying osteoarthritis and preventing further surgery.
Journal ArticleDOI
One-Step Surgery With Multipotent Stem Cells for the Treatment of Large Full-Thickness Chondral Defects of the Knee
TL;DR: The treatment of large chondral defects with MSCs is an effective procedure and can be performed routinely in clinical practice, and is achieved with 1-step surgery, avoiding a previous surgical procedure to harvest cartilage and subsequent chondrocyte cultivation.
Journal ArticleDOI
Repair of Damaged Articular Cartilage: Current Approaches and Future Directions.
Ekaterina V Medvedeva,Ekaterina A. Grebenik,Svetlana N Gornostaeva,Vladimir I Telpuhov,Aleksey V. Lychagin,Peter S. Timashev,Andrei S. Chagin +6 more
TL;DR: Current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice are discussed, and potential future directions in this area are described, including tissue engineering based on scaffolding and/or stem cells aswell as a combination of gene and cell therapy.
References
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Journal ArticleDOI
Rating systems in the evaluation of knee ligament injuries.
Yelverton Tegner,Jack Lysholm +1 more
TL;DR: A new activity grading scale, where work and sport activities were graded numerically, was constructed as complement to the functional score, showing that the symptom-related score gave a more differentiated picture of the disability.
Journal ArticleDOI
Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure
TL;DR: The KOOS proved reliable, responsive to surgery and physical therapy, and valid for patients undergoing anterior cruciate ligament reconstruction, and can be used to evaluate the course of knee injury and treatment outcome.
Journal ArticleDOI
Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale
Jack Lysholm,Jan Gillquist +1 more
TL;DR: A scoring scale for knee ligament surgery follow-up emphasizing evaluation of symp toms of instability better than the modified Larson scale, which gave basically the same results in patients with menis cus rupture.
Journal ArticleDOI
Development and Validation of the International Knee Documentation Committee Subjective Knee Form
James J. Irrgang,Allen F. Anderson,Arthur L. Boland,Christopher D. Harner,Masahiro Kurosaka,Phillipe Neyret,John C. Richmond,K. Donald Shelborne +7 more
TL;DR: The International Knee Documentation Committee Subjective Knee Form is a reliable and valid knee-specific measure of symptoms, function, and sports activity that is appropriate for patients with a wide variety of knee problems.