Journal ArticleDOI
Low platelet monoamine oxidase activity and chronic marijuana use
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Mean platelet monoamine oxidase activity in 26 consecutively-studied male marijuana smokers was significantly lower than in a comparable group of non-marijuana smoking males, and the level of current marijuana use reported by the subjects was significantly and inversely correlated with MAO activity.About:
This article is published in Life Sciences.The article was published on 1978-10-16. It has received 45 citations till now. The article focuses on the topics: Monoamine oxidase.read more
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Reckless behavior in adolescence: A developmental perspective
TL;DR: In this article, a developmental theory of reckless behavior among adolescents is presented, in which sensation seeking and adolescent egocentrism are especially prominent factors, and factors that may be responsible for the decline of reckless behaviour with age are discussed.
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Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review
Stephen M. Stout,Nina M. Cimino +1 more
TL;DR: In vitro data were identified that characterize cytochrome P-450 (CYP-450) enzymes as potential significant contributors to the primary metabolism of several exogenous cannabinoids, and clinical pharmacogenetic data further support CYP2C9 as a significant contributor to THC metabolism, and a pharmacokinetic interaction study using ketoconazole with oromucosal cannabis extract further supports CYP3A4 as asignificant metabolic pathway for THC and CBD.
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Personality in the third dimension: A psychobiological approach☆
TL;DR: In this paper, an attempt is made to define the P dimension of personality in terms of its constituent traits, biological correlates, genetic bases, and relation to forms of psychopathology, and factor analyses revealed a coherent P supertrait incorporating the narrower traits of impulsivity, sensation seeking, lack of socialization and responsibility, autonomy, and aggression.
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Personality traits related to monoamine oxidase activity in platelets
TL;DR: Low MAO subjects were found to be more sensation seeking and to have higher scores on impulsivity and monotony avoidance, and this subgroup seems to be the real "high risk" group that could be expected to show more alcohol abuse and higher tendencies to suicidal behavior.
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Low platelet monoamine oxidase activity in cigarette smokers.
TL;DR: The activity of platelet monoamine oxidase was found to be significantly lower in normal female subjects who smoked at least 5 cigarettes per day than in non-smokers, a finding that may be related to both smoking and to low MAO activity.
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The biochemical high-risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity
TL;DR: Families of low MAO probands had an eightfold increase in the incidence of suicide or suicide attempts over those of high-MAO Probands, suggesting that reduced MAO levels may predict a vulnerability to psychiatric disorder.
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Platelet and plasma amine oxidase activity in 680 normals: Sex and age differences and stability over time
TL;DR: Platelet and plasma amine oxidase activities in 680 normals exhibited unimodal frequency distributions and Females had 20% higher mean platelet amine oxidation activities, but there were no male-female differences in the plasma enzyme.
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Reduced Monoamine Oxidase Activity in Blood Platelets from Bipolar Depressed Patients
Dennis L. Murphy,Richard Weiss +1 more
TL;DR: Cellular monoamine oxidase activity measured in blood platelets is significantly lower in depressed patients with a history of mania than in nonbipolar depressed patients and normal controls of similar age and sex.
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Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia.
Richard Jed Wyatt,Dennis L. Murphy,Robert H. Belmaker,Stanley N. Cohen,C. H. Donnelly,William Pollin +5 more
TL;DR: The data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia.
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Biogenic amine-related enzymes and personality variations in normals.
D. L. Murphy,Robert H. Belmaker,Monte S. Buchsbaum,N. F. Martin,R. Ciaranello,Richard Jed Wyatt +5 more
TL;DR: No associations were observed between plasma dopamine beta-hydroxylase activities and the personality variables and, in contrast, the amine oxidase results showed positive correlations between psychological test scores and personality variables.
Related Papers (5)
Platelet and plasma amine oxidase activity in alcoholic individuals.
L F Major,Dennis L. Murphy +1 more