Journal ArticleDOI
Lysosomal changes related to exercise injuries and training‐induced protection in mouse skeletal muscle
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TLDR
The observations suggest that the severity of exercise injuries is related to the strength of the exercise stimulus and the level of preceding physical activity and can be characterized by the lysosomal changes.Citations
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Exercise-Induced Muscle Damage and Adaptation
TL;DR: Physical conditioning results in an adaptation such that all indicators of damage are reduced following repeated bouts of exercise, and investigators have suggested that the prophylactic effect of training may be due to performance of a single initial exercise bout.
Journal Article
Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?
TL;DR: The evidence that exercise can cause muscle damage and inflammation in otherwise healthy human skeletal muscles is addressed and it is proposed that muscle damage as evaluated by changes in muscle function is related to leucocyte accumulation in the exercised muscles.
Journal ArticleDOI
Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.
Hyo Youl Moon,Andreas Becke,David Berron,Benjamin Becker,Nirnath Sah,Galit Benoni,Emma Janke,Susan T. Lubejko,Nigel H. Greig,Julie A. Mattison,Emrah Düzel,Emrah Düzel,Henriette van Praag +12 more
TL;DR: It is shown that a muscle secretory factor, cathepsin B (CTSB) protein, is important for the cognitive and neurogenic benefits of running, and CTSB as a mediator of effects of exercise on cognition is suggested.
Journal ArticleDOI
Exercise, muscle damage and fatigue.
TL;DR: The symptoms and events occurring during delayed onset of muscle soreness (DOMS) can be explained by a cascade of events following structural damage to muscle proteins.
Journal ArticleDOI
Muscle damage and endurance events.
TL;DR: There is no compelling evidence that any drug treatment or preventative measures will lessen chronic muscle injury, which suggests that high local tensions in fibres may be more important than metabolic considerations in the aetiology of the injury.
References
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Journal ArticleDOI
Creatine kinase and glutamic oxalacetic transaminase activity in serum: kinetics of change with exercise and effect of physical conditioning.
TL;DR: Serum creatine kinase and glutamic oxalacetic transaminase activity following a standardized 6 minute period of moderately severe exercise has been studied in normal women and normal men before and after a 3 to 5 week period of physical conditioning.
Journal ArticleDOI
Exhaustive exercise, endurance training, and acid hydrolase activity in skeletal muscle
TL;DR: Exhaustive exercise causes lethal and evidently also sublethal fiber injuries manifesting themselves as an activation of the lysosomal system of muscle fibers 5 days later, and training affects cellular homeostasis by causing an apparent resistance to the damaging effects of exhaustive exercise.
Journal ArticleDOI
Muscular dystrophy and activation of proteinases.
Nirmal C. Kar,Carl M. Pearson +1 more
TL;DR: Evidence is presented for the existence of many different systems of proteolytic enzymes in human skeletal muscle, including the lysosomal system of cathepsins as well as proteinases and peptide hydrolases that are optimally active at neutral and alkaline pH ranges.
Journal ArticleDOI
Exertional rhabdomyolysis with myoglobinuria in a large group of military trainees
Jack O. Greenberg,Leslie Arneson +1 more
TL;DR: The phenomenon is not rare, as previously reported, and a total of 35 patients with exertional rhabdomyolysis has been reported in the literature.
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