Journal ArticleDOI
Autophagic response to strenuous exercise in mouse skeletal muscle fibers.
A Salminen,V Vihko +1 more
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TLDR
It is proposed that increased autophagic activity could be related to the breakdown of cellular constituents of surviving muscle fibers to provide structural elements for regenerating muscle fibers.Abstract:
Strenuous physical exercise induces necrosis of skeletal muscle fibers and increases lysosomal enzyme activities in surviving muscle fibers. This study examines the ultrastructural basis of the stimulation of the lysosomal system in mouse vastus medialis muscle during the appearance and repair of exercise-induced (9 h of running) injuries. Necrotic fibers appeared the day after exercise and an inflammatory response with the replacement of necrotic fibers by phagocytes was highest 2-3 days after exertion. Ultrastructural study of surviving muscle fibers revealed numerous autophagic vacuoles, residual bodies, and spheromembranous structures at the periphery of myofibers, especially in fibers adjacent to necrotic fibers. The autophagic response was most prominent between 2 and 7 days after exertion. Autophagic vacuoles with double or single limiting membranes contained mitochondria at various stages of degradation. Vacuolar and multilamellar structures were also observed in regenerating muscle fibers. The structure of injured skeletal muscle fibers returned to normal within 2 weeks. It is proposed that increased autophagic activity could be related to the breakdown of cellular constituents of surviving muscle fibers to provide structural elements for regenerating muscle fibers.read more
Citations
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Journal ArticleDOI
Exercise-Induced Muscle Damage and Adaptation
TL;DR: Physical conditioning results in an adaptation such that all indicators of damage are reduced following repeated bouts of exercise, and investigators have suggested that the prophylactic effect of training may be due to performance of a single initial exercise bout.
Journal Article
Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?
TL;DR: The evidence that exercise can cause muscle damage and inflammation in otherwise healthy human skeletal muscles is addressed and it is proposed that muscle damage as evaluated by changes in muscle function is related to leucocyte accumulation in the exercised muscles.
Journal ArticleDOI
Injury to skeletal muscle fibers of mice following lengthening contractions.
Kevin K. McCully,J. A. Faulkner +1 more
TL;DR: It is concluded that, with the protocol used, lengthening, but not isometric or shortening contractions, caused significant injury to muscle fibers.
Journal ArticleDOI
Autophagy in Ischemic Heart Disease
TL;DR: The evidence for autophagy in the heart in response to ischemia and reperfusion is discussed, factors that regulate autophagic activity are identified, and the potential roles Autophagy might play in cardiac cells are analyzed.
Journal ArticleDOI
Role of LAMP-2 in Lysosome Biogenesis and Autophagy
Eeva-Liisa Eskelinen,Anna Lena Illert,Yoshitaka Tanaka,Günter Schwarzmann,Judith Blanz,Kurt von Figura,Paul Saftig +6 more
TL;DR: The data indicate that in hepatocytes LAMP-2 deficiency either directly or indirectly leads to impaired recycling of 46-kDa mannose 6-phosphate receptors and partial mistargeting of a subset of lysosomal enzymes.
References
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Journal Article
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TL;DR: It is suggested that lysosomal autophagy is important in the efforts at repair that cardiac cells initiate during and after hypoxia.
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