Book ChapterDOI
Management and Control of Antimalarial Drug Resistance
Amrita Chakrabarti,Vigyasa Singh,Shailja Singh +2 more
- pp 297-322
TLDR
The demographical distribution of malaria throughout the world along with its clinical manifestations is discussed and effect of wide spectrum usage of antimalarials and combinational therapy against the deadly disease is described.Abstract:
Resistance to antimalarial drugs is a great threat to malaria elimination efforts and adds resurgency of malaria incidences and deaths. Rapid and indiscriminate use of drugs in the treatment of malarial infections has led to the emergence and spread of resistant strains. With condensed efforts for monitoring drugs resistance in clinical setup integrated by in vitro drug susceptibility assays and analysis of resistance markers can help in malaria eradication policy. In this chapter we discussed the demographical distribution of malaria throughout the world along with its clinical manifestations. We have also emphasized the mechanism of action underlying activity of FDA approved antimalarial drugs and also described effect of wide spectrum usage of antimalarials and combinational therapy against the deadly disease. Various factors leading to emergence of resistance including the mutation rate of the parasite for their bio-adaptation, the overall parasite load, strength of drug selection and treatment compliance. We summarize the chapter stating the number of probabilities which defines the future of antimalarial drug resistance and cumulative approaches to combat it.read more
References
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Journal ArticleDOI
Origins and Evolution of Antibiotic Resistance
Julian Davies,Dorothy Davies +1 more
TL;DR: A review of antibiotic resistance development over the past half-century can be found in this article, with the oft-restated conclusion that it is time to act and to restore the therapeutic applications of antibiotics.
Journal ArticleDOI
Role of the Microbiota in Immunity and Inflammation
Yasmine Belkaid,Timothy W. Hand +1 more
TL;DR: In high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses.
Journal ArticleDOI
Rapid Diagnostic Tests for Malaria Parasites
TL;DR: Most new technology for malaria diagnosis incorporates immunochromatographic capture procedures, with conjugated monoclonal antibodies providing the indicator of infection, and clinical studies allow effective comparisons between different formats.
Journal ArticleDOI
The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland
Helena Seppälä,Timo Klaukka,Jaana Vuopio-Varkila,Anna Muotiala,Hans Helenius,Katrina Lager,Pentti Huovinen +6 more
TL;DR: In Finland, after nationwide reductions in the use of macrolide antibiotics for outpatient therapy, there was a significant decline in the frequency of erythromycin resistance among group A streptococci isolated from throat swabs and pus samples.