Journal ArticleDOI
Manufacturing Nanosized Fenofibrate by Salt Assisted Milling
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TLDR
The nano-sized fenofibrate demonstrates faster dissolution kinetics in aqueous media, simulating stomach environment, within the first 60 min as compared to the micronized form.Abstract:
Purpose
The aim of this study is to develop a new process for manufacturing a nano-sized form of the popular cholesterol-reducing drug fenofibrate which can be implemented on industrial scale with minimal changes of currently used production schemes.read more
Citations
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Journal ArticleDOI
Biomedical applications of nanodiamond (Review).
TL;DR: This review covers the recent progress as well as general trends in biomedical applications of nanodiamond, and underlines the importance of purification, characterization, and rational modification of this nanomaterial when designing nanod diamond based theranostic platforms.
Journal ArticleDOI
Adsorption of drugs on nanodiamond: toward development of a drug delivery platform.
Vadym Mochalin,Amanda Pentecost,Xue-Mei Li,Ioannis Neitzel,Matthew Nelson,Chongyang Wei,Tao He,Fang Guo,Yury Gogotsi +8 more
TL;DR: A physical-chemical study of the adsorption of doxorubicin and polymyxin B on nanodiamonds is reported, analyzing the role of purification and surface chemistry of the Adsorbent.
Journal ArticleDOI
Deaggregation of Nanodiamond Powders Using Salt- and Sugar-Assisted Milling
TL;DR: Using the dry media assisted milling with subsequent pH adjustment, it is possible to produce stable aqueous nanodiamond colloidal solutions with particles <10 nm in diameter, which corresponds to 1-2 primary nanod diamond particles.
Journal ArticleDOI
Increasing biochar surface area: Optimization of ball milling parameters
TL;DR: In this article, a planetary ball mill was used to increase the surface area of the biochar, and various milling parameters were examined to see which had the largest effect on surface area.
Journal ArticleDOI
Salt-Assisted Ultrasonic Deaggregation of Nanodiamond
TL;DR: A new facile, inexpensive, and contaminant-free technique of salt-assisted ultrasonic deaggregation of nanodiamond into single-digit particles stable in aqueous colloidal solution in a wide pH range is reported.
References
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Journal ArticleDOI
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
TL;DR: A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption.
Journal ArticleDOI
Nanosizing: a formulation approach for poorly-water-soluble compounds.
TL;DR: NanoCrystal Technology is an attrition process wherein large micron size drug crystals are media milled in a water-based stabilizer solution and the process generates physically stable dispersions consisting of nanometer-sized drug crystals.
Journal ArticleDOI
Role of surfactant and pH on dissolution properties of fenofibrate and glipizide--a technical note.
Shahla Jamzad,Reza Fassihi +1 more
TL;DR: Depending on the dose size and solubility characteristics of low Solubility drugs, a meaningful and discriminatory power of dissolution rate testing can be demonstrated.
Journal ArticleDOI
A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution.
TL;DR: A new approach in the correlation between particle size and dissolution may be an important analytical tool in the engineering of the particle size distribution of drug substance, and more precisely monitoring the D[4, 3] volume-weighted mean diameter may allow one to model the dissolution profile of a suspension formulation and thereby its in vivo release profile.
Journal Article
Mechanism of action of fibrates
TL;DR: Fibrates stimulate LDL receptor-dependent clearance mechanisms and reduce the amount of LDL available for oxidation, the fraction which is most likely to generate peroxidation products.
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