Journal ArticleDOI
Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14.
TLDR
A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three allele at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described and the allelic constitution at these loci for 44 inbred strains and stocks was determined.Abstract:
A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was established by backcross experiments in which alleles at Np-1 and Robertsonian translocations were segregating. Es-10 was shown to be linked to Np-1, and the following genetic map of Chr 14 was constructed: centromere-(8.9±4.0 cM)-[Np-1, Wc]-(10.2±1.9 cM)-Es-10-(15.5±3.7 cM)-s. The homologous human loci, NP and ES-D, are not linked.read more
Citations
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Journal ArticleDOI
Abrupt cline for sex chromosomes in a hybrid zone between two species of mice.
TL;DR: The limited flow of both X‐ and Y‐specific alleles suggest that sex chromosomes have played an important role in Mus speciation and may contribute to hybrid breakdown between two species.
Journal ArticleDOI
Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Interaction of the Ah and hr loci
Joyce C. Knutson,Alan Poland +1 more
TL;DR: A genetic model for the interaction of the Ah and hr loci is proposed, to account for the differential response to TCDD observed in the skin of HRS/J hr/hr and hr/+ mice.
Journal ArticleDOI
Comparative map for mice and humans.
Joseph H. Nadeau,Muriel T. Davisson,Donald P. Doolittle,Patricia Grant,Alan L. Hillyard,Michael Kosowsky,Thomas H. Roderick +6 more
TL;DR: This report summarizes the status of this comparative map and provided a listing of homologous genes and anonymous loci that have been mapped in mice and humans together with references documenting homology and the chromosomal and linkage assignments.
Journal ArticleDOI
Recombination suppression by heterozygous Robertsonian chromosomes in the mouse.
M T Davisson,E C Akeson +1 more
TL;DR: The data provide evidence that the underlying mechanism of recombination suppression is mechanical interference in meiotic pairing between Robertsonian chromosomes and their telocentric partners, and suggest that the pairing delay is caused by minor structural differences between the Robertsonian chromosome and theirTelocentric homologs.
Journal ArticleDOI
hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis.
TL;DR: The isolation of such a mutation, hph-1, causing a heritable hyperphenylalaninemia in the neonate and weanling and an inability to effectively clear a phenylalanine challenge in the adult is described.
References
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Journal ArticleDOI
Esterase D: a new human polymorphism
TL;DR: The present paper describes yet a further human red cell esterase, which is different from the red cell A, B aiid C esterases, the carbonic anhydrase isozymes, and from acetylcholinesterase in their structure and function.
Journal ArticleDOI
A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.
TL;DR: The polymorphism and electrophoretic phenotypes and staining conditions for 30 enzymes which may be examined in somatic cell hybrids of’ mouse, human or Chinese hamster cell lines are reviewed.
Journal ArticleDOI
Myoglobin: Inherited Structural Variation in Man
TL;DR: Ultrafiltrates of human myoglobin from 200 individuals were examined by starch-gel electrophoresis and chromatography indicate a loss of arginine at a position near the C-terminal portion of the molecule.
Journal ArticleDOI
An improved banding technique exemplified in the karyotype analysis of two strains of rat.
P. H. Gallimore,C. R. Richardson +1 more
TL;DR: Using an improved Giemsa banding technique karyotypes were prepared from cells of two strains of laboratory rat (AS and Hooded Lister) without loss of chromosome morphology and consistent banding patterns were found in both early and late metaphase cells.
Journal ArticleDOI
Inherited variants of human nucleoside phosphorylase.
TL;DR: Multiple NP isozymes were found in most human tissues and the best resolution was achieved by electrophoresis in a buffer system containing lithium ions.
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