Maternal Pre-pregnancy BMI, Gestational Weight Gain, and Age at Menarche in Daughters
Julianna Deardorff,Rachel Berry-Millett,David H. Rehkopf,Ellen Luecke,Maureen Lahiff,Barbara Abrams +5 more
TLDR
Maternal factors, before and during pregnancy, are potentially important determinants of daughters’ menarcheal timing and are amenable to intervention.Abstract:
Life course theory suggests that early life experiences can shape health over a lifetime and across generations. Associations between maternal pregnancy experience and daughters’ age at menarche are not well understood. We examined whether maternal pre-pregnancy BMI and gestational weight gain (GWG) were independently related to daughters’ age at menarche. Consistent with a life course perspective, we also examined whether maternal GWG, birth weight, and prepubertal BMI mediated the relationship between pre-pregnancy BMI and daughter’s menarcheal age. We examined 2,497 mother-daughter pairs from the 1979 National Longitudinal Survey of Youth. Survival analysis with Cox proportional hazards was used to estimate whether maternal pre-pregnancy overweight/obesity (BMI ≥ 25.0 kg/m2) and GWG adequacy (inadequate, recommended, and excessive) were associated with risk for earlier menarche among girls, controlling for important covariates. Analyses were conducted to examine the mediating roles of GWG adequacy, child birth weight and prepubertal BMI. Adjusting for covariates, pre-pregnancy overweight/obesity (HR = 1.20, 95 % CI 1.06, 1.36) and excess GWG (HR = 1.13, 95 % CI 1.01, 1.27) were associated with daughters’ earlier menarche, while inadequate GWG was not. The association between maternal pre-pregnancy weight and daughters’ menarcheal timing was not mediated by daughter’s birth weight, prepubertal BMI or maternal GWG. Maternal factors, before and during pregnancy, are potentially important determinants of daughters’ menarcheal timing and are amenable to intervention. Further research is needed to better understand pathways through which these factors operate.read more
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Key steps for effective breast cancer prevention
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Nongenetic determinants of age at menarche: a systematic review.
TL;DR: The factors affecting prenatal and early childhood growth seem to have a larger effect on further sexual maturation, and the data about influence of nongenetic factors on AAM are still inconsistent.
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Nutritional Determinants of the Timing of Puberty
Eduardo Villamor,Erica C. Jansen +1 more
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Maternal Oral Bacterial Levels Predict Early Childhood Caries Development
Benjamin W. Chaffee,Stuart A. Gansky,Jane A. Weintraub,Jane A. Weintraub,John D. B. Featherstone,Francisco Ramos-Gomez,Francisco Ramos-Gomez +6 more
TL;DR: Maternal salivary bacterial challenge not only is associated with oral infection among children but also predicts increased early childhood caries occurrence.
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TL;DR: The findings indicate that the prevalence of fetal growth restriction (FGR) will vary markedly, depending on the fetal growth curve used, and many previously published fetal growth curves no longer provide an up-to-date reference for describing the distribution of birth weight by gestational age.
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