Mechanism of Action of Bimatoprost, Latanoprost, and Travoprost in Healthy Subjects: A Crossover Study
K. Sheng Lim,K. Sheng Lim,Cherie B Nau,Megan M. O’Byrne,David O. Hodge,Carol B. Toris,Jay W. McLaren,Douglas H. Johnson +7 more
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TLDR
In this article, the effects of three prostaglandin analogs, bimatoprost, latanoprost and travoprost on aqueous dynamics in the same subjects and to compare techniques of assessing outflow facility were studied.About:
This article is published in Ophthalmology.The article was published on 2008-05-01 and is currently open access. It has received 147 citations till now. The article focuses on the topics: Latanoprost & Bimatoprost.read more
Citations
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Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction
TL;DR: Recent animal and clinical studies of the effects of topical prostaglandin analogs on aqueous humor dynamics and recent cellular and molecular studies designed to clarify the outflow effects are summarized.
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Uveoscleral outflow--a review.
Albert Alm,Siv F.E. Nilsson +1 more
TL;DR: The uveoscleral outflow route was described more than 40 years ago as discussed by the authors and 40% of aqueous leaves the eye through the iris root, with results suggesting a similar fraction, at least in eyes from younger individuals.
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Recent Research on the Health Benefits of Blueberries and Their Anthocyanins.
Wilhelmina Kalt,Aedin Cassidy,Luke R. Howard,Robert Krikorian,April J. Stull,François Tremblay,Raul Zamora-Ros +6 more
TL;DR: More evidence, and particularly human clinical evidence, is needed to better understand the potential for anthocyanin-rich blueberries to benefit public health, but it is widely agreed that the regular consumption of tasty, ripe blueberries can be unconditionally recommended.
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Unconventional aqueous humor outflow: A review
TL;DR: The mouse appears to be a promising model because it captures several aspects of conventional and unconventional outflow dynamics common to humans, although questions remain regarding the magnitude of unconventional out flow in mice.
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Pulsatile flow into the aqueous veins: Manifestations in normal and glaucomatous eyes
TL;DR: A summary of in vivo IOP-induced patterns of cyclic flow that can be used as part of a framework for interpretation of responses to cyclic stresses identified in the laboratory are provided.
References
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Experimental aqueous perfusion in enucleated human eyes.
TL;DR: In study of the mechanics of the outflow channels, good use has been made of aqueous perfusion of the eye when in vivo or in study of elastic properties of the eyes.
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A comparison of latanoprost, bimatoprost, and travoprost in patients with elevated intraocular pressure: A 12-week, randomized, masked-evaluator multicenter study
TL;DR: Latanoprost exhibited greater ocular tolerability and bimatoprost and travoprost were comparable in their ability to reduce intraocular pressure in OAG and OH patients.
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Effects of PhXA41, A New Prostaglandin F2α Analog, on Aqueous Humor Dynamics in Human Eyes
TL;DR: PhXA41, a new phenyl-substituted analog of a prostaglandin F 2α (PGF 2α ) prodrug, is an effective ocular hypotensive agent in patients with glaucoma as well as other parameters of aqueous humor dynamics.
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Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension
Peter A. Netland,Theresa A. Landry,E. Kenneth Sullivan,Russell M. Andrew,Lewis H. Silver,Alan L. Weiner,Sushanta Mallick,Jaime E. Dickerson,Michael V. W. Bergamini,Stella M. Robertson,Alberta A Davis +10 more
TL;DR: Travoprost (0.0015% and 0.004%) was more effective than latanoprost and timolol in reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension as discussed by the authors.
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Aqueous humor dynamics in the aging human eye
TL;DR: In the healthy aging eye, there is a Reduction in the production of aqueous humor and a reduction in its drainage through the uveoscleral outflow pathway.