Journal ArticleDOI
Mechanism of pyruvate dehydrogenase activation by increased cardiac work
Kumpei Kobayashi,James R. Neely +1 more
TLDR
The increase in active PDH with higher levels of cardia work was associated most closely with reduced mitochondrial NADH/NAD ratios and with decreased acetyl CoA/CoA ratios when insulin or pyruvate were present.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 1983-06-01. It has received 82 citations till now. The article focuses on the topics: Pyruvate decarboxylation & Pyruvate dehydrogenase complex.read more
Citations
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Journal ArticleDOI
Control of respiration and ATP synthesis in mammalian mitochondria and cells.
TL;DR: There is no simple answer to the question 'what controls respiration?' the answer varies with the size of the system examined (mitochondria, cell or organ), the conditions (rate of ATP use, level of hormonal stimulation), and the particular organ examined.
Journal ArticleDOI
Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics
Brian Glancy,Robert S. Balaban +1 more
TL;DR: Though most specific molecular mechanisms have yet to be elucidated, it is clear that Ca(2+) provides a balanced activation of mitochondrial energy metabolism that exceeds the alteration of dehydrogenases alone.
Journal ArticleDOI
Transport of oxygen in muscle.
TL;DR: This work addresses intracellular events within the myocyte with particular attention to the role of myoglobin, and asks how the massive and variable flow of oxygen to muscle mitochondria is achieved at near-constant low sarcoplasmic oxygen pressure.
Journal ArticleDOI
Regulation of oxidative phosphorylation in the mammalian cell.
TL;DR: The potential sites within oxidative phosphorylation which may be regulated through cytosolic transducers to result in the necessary feedback network regulating the steady-state flow of energy in the cell are reviewed.
Journal ArticleDOI
Cardiac energy metabolism homeostasis: role of cytosolic calcium.
TL;DR: A model of the cardiac energy metabolism control network is proposed that includes a Ca(2+) parallel activation component together with more classical elements including metabolite feedback and cytosolic compartmentation.
References
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Journal ArticleDOI
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
James R. Neely,H E Morgan +1 more
TL;DR: Fatty acid oxidation is suppressed in ischemic hearts leading to accumulation of long-chained CoA derivatives and increase in triglyceride levels, and the acceleration of flux through glycolysis may be as much as 10to 20-fold.
Journal ArticleDOI
Effect of pressure development on oxygen consumption by isolated rat heart.
TL;DR: Variation in mechanical performance and oxygen consumption with hearts of various sizes has been noted, indicating that meaningful comparisons of performance must utilize hearts of similar size.
Book ChapterDOI
[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods
TL;DR: This chapter is based on the assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods based on instruments capable of giving a full-scale deflection of the recorder with 0.25μM NADH, with a noise level less than 2%.
Journal ArticleDOI
α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION
TL;DR: The discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney mitochondria is regulated by a phosphorylation-dephosphorylation reaction sequence is reported.
Journal ArticleDOI
Effects of pH and free Mg2+ on the Keq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions.
J W Lawson,R L Veech +1 more
TL;DR: The observed equilibrium constants (Kobs) of the creatine kinase, myokinase, glucose-6-phosphatase, and fructose-1,6-diph phosphatase reactions have been determined at 38 degrees C, pH 7.0, ionic strength 0.25, and varying free magnesium concentrations.