Journal ArticleDOI
Mechanism of repair of DNA in bacteriophage: I. Excision of pyrimidine dimers from ultraviolet-irradiated DNA by an extract of T4-infected cells☆
Mutsuo Sekiguchi,Seiichi Yasuda,Shunzo Okubo,Hiroaki Nakayama,Kazunori Shimada,Yasuyuki Takagi +5 more
TLDR
It is likely that enzyme(s) responsible for excision of dimers is induced by infection with T4, and the excision in vitro is similar to the reaction observed in vivo in ultraviolet-resistant cells.About:
This article is published in Journal of Molecular Biology.The article was published on 1970-01-28. It has received 67 citations till now. The article focuses on the topics: Pyrimidine dimer & Thymine.read more
Citations
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Journal ArticleDOI
Bacteriophage T4 Genome
TL;DR: T4 functional genomics will aid in the interpretation of these newly sequenced T4-related genomes and in broadening the understanding of the complex evolution and ecology of phages—the most abundant and among the most ancient biological entities on Earth.
Book ChapterDOI
2 – Photochemistry of DNA and Polynucleotides: Photoproducts
M.H. Patrick,R.O. Rahn +1 more
Journal ArticleDOI
T4 Endonuclease Involved in Repair of DNA
Seiichi Yasuda,Mutsuo Sekiguchi +1 more
TL;DR: An enzyme activity, named T4 endonuclease V, was purified from T4-infected Escherichia coli and appears to be responsible for the first step of excision repair.
Journal ArticleDOI
Dark Repair of Ultraviolet-Irradiated Deoxyribonucleic Acid by Bacteriophage T4: Purification and Characterization of a Dimer-Specific Phage-Induced Endonuclease
Errol C. Friedberg,John J. King +1 more
TL;DR: The purification and properties of an ultraviolet (UV) repair endonuclease are described and the specific substrate in UV-irradiated DNA appears to be pyrimidine dimer sites.
Book ChapterDOI
Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing?
TL;DR: The chapter presents the reports of photoreactivation that specify that the damage brought about by a particular wavelength of light irradiation could be annulled or prevented by radiation with others.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Sedimentation studies of the size and shape of dna.
TL;DR: Analytical zone sedimentation ( Vinograd, Bruner, Kent & Weigle, 1963) is shown to be a sensitive and reliable method for detecting differences in conformation and for determining the molecular weight of homogeneous phage DNA's.
Journal ArticleDOI
Preparation of transforming deoxyribonucleic acid by phenol treatment
Hiuga Saito,Kin-ichiro Miura +1 more
TL;DR: The final DNA preparation has high transforming activity, especially for the joint transformation of linked markers, as well as high purity and low sedimentation coefficients.
Journal ArticleDOI
Defective repair replication of DNA in xeroderma pigmentosum.
TL;DR: Patients with xeroderma pigmentosum develop fatal skin cancers when exposed to sunlight, and so the failure of DNA repair in the skin must be related to carcinogenesis.