Journal ArticleDOI
Mechanisms of Tissue Injury in Cryosurgery
Andrew A. Gage,John G. Baust +1 more
TLDR
A prime need in cryosurgery research is related to the periphery of the cryosurgical lesion where some cells die and others live, and adjunctive therapy should influence the fate of cells in this region and increase the efficacy of cryos surgical techniques.About:
This article is published in Cryobiology.The article was published on 1998-11-01. It has received 944 citations till now. The article focuses on the topics: Cryosurgery.read more
Citations
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Journal ArticleDOI
Thermal ablation of tumours: biological mechanisms and advances in therapy.
Katrina F. Chu,Damian E. Dupuy +1 more
TL;DR: The mechanisms of tumour cell death that are induced by the most common thermoablative techniques are examined and the rapidly developing areas of research in the field are discussed, including combinatorial ablation and immunotherapy, synergy with conventional chemotherapy and radiation, and the development of a new ablation modality in irreversible electroporation.
Journal ArticleDOI
The cryobiology of cryosurgical injury.
TL;DR: Cryosurgery, or tissue destruction by controlled freezing, has been investigated as a possible alternative to surgical intervention in the treatment of many diseases and has the potential for less invasiveness and lower morbidity compared with surgical excision.
Journal ArticleDOI
The molecular basis of cryosurgery
John G. Baust,Andrew A. Gage +1 more
TL;DR: From the molecular perspective, the most important advance in basic research related to cryosurgery is the recognition that apoptosis is a mechanism of cell death after cold injury.
Journal ArticleDOI
Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation--what should you use and why?
TL;DR: Suggested algorithms are described that will help physicians choose among the various ablation modalities for individual patients, and combining an understanding of the physical properties of the ablationmodalities with an understandingof the thermal kinetics in tissue are key to optimizing clinical outcomes.
Journal ArticleDOI
Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti–CTLA-4 Therapy
Rebecca Waitz,Stephen B. Solomon,Elena N. Petre,Anne E. Trumble,Marcella Fasso,Larry Norton,James P. Allison +6 more
TL;DR: Although cryoablation is currently used to treat a targeted tumor nodule, the results suggest that combination therapy with CTLA-4 blockade will augment antitumor immunity and rejection of tumor metastases in this setting.
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Freezing of living cells: mechanisms and implications
TL;DR: A new view of the mechanism of slow freezing injury ought to facilitate the development of procedures for the preservation of complex assemblages of cells of biological, medical, and agricultural significance.
Book ChapterDOI
The Immune System
TL;DR: In this article, a mouse is injected subcutaneously with a suspension of appropriate bacteria, and either the mouse falls ill and succumbs to the infection within a few days, or it recovers.
Journal ArticleDOI
Kinetics of water loss from cells at subzero temperatures and the likelihood of intracellular freezing.
TL;DR: The present study derives a quantitative relation between the amount of water in a cell and temperature using a differential equation involving cooling rate, surface-volume ratio, membrane permeability to water, and the temperature coefficient of the permeability constant.