Journal ArticleDOI
Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation
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TLDR
Findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.Abstract:
Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.read more
Citations
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Journal ArticleDOI
The variability of female reproductive ageing
TL;DR: Age at last birth in natural fertility populations, which marks the end of female fertility, shows an identically wide variation as age at menopause, but occurs on average 10 years earlier than this, given the high heritability for age atMenopause.
Journal ArticleDOI
Treatment of symptoms of the menopause: an Endocrine Society Clinical Practice Guideline
Cynthia A. Stuenkel,Cynthia A. Stuenkel,Susan R. Davis,Anne Gompel,Mary Ann Lumsden,Mary Ann Lumsden,M. Hassan Murad,JoAnn V. Pinkerton,JoAnn V. Pinkerton,Richard J. Santen,Richard J. Santen +10 more
TL;DR: Menopausal hormone therapy (MHT) is the most effective treatment for vasomotor symptoms and other symptoms of the climacteric and benefits may exceed risks for the majority of symptomatic postmenopausal women who are under age 60 or under 10 years since the onset of menopause.
Journal ArticleDOI
Hot Flashes: Epidemiology and Physiologya
TL;DR: The prospective and retrospective descriptions of hot flashes provide a more detailed profile of the hot flash than has previously been available and data indicate that hot flashes may start much earlier and continue far longer than is commonly recognized by physicians or acknowledged in textbooks of gynecology.
Journal ArticleDOI
Physiology of hot flashes.
TL;DR: Evidence obtained using a rapidly responding ingested telemetry pill indicates that the thermoneutral zone, within which sweating, peripheral vasodilation, and shivering do not occur, is virtually nonexistent in symptomatic women but normal in asymptomatic women.
Journal ArticleDOI
Lifestyle and Demographic Factors in Relation to Vasomotor Symptoms: Baseline Results from the Study of Women’s Health Across the Nation
Ellen B. Gold,Gladys Block,Sybil L. Crawford,Laurie Lachance,Gordon FitzGerald,Heidi L. Miracle,Sheryl Sherman +6 more
TL;DR: In this article, the authors examined the relation of such factors to vasomotor symptoms in the multiethnic sample of 3,302 women, aged 42-52 years at baseline (1995-1997), in the Study of Women's Health Across the Nation (SWAN).
References
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Journal ArticleDOI
Episodic Luteinizing Hormone Secretion in Man PULSE ANALYSIS, CLINICAL INTERPRETATION, PHYSIOLOGIC MECHANISMS
Richard J. Santen,C. W. Bardin +1 more
TL;DR: In this article, the authors demonstrate that luteinizing hormone (LH) release from the pituitary is episodic rather than constant, which raises fundamental questions regarding the physiologic control of pulsatile LH secretion and its possible alteration in patients with gonadal disorders.
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Surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. I. Gonadotropin secretion.
TL;DR: Observations suggest that the mechanisms underlying the diurnal rhythm in cortisol secretion, as well as those mediating the discharges of GH in response to vasopressin administration and insulin hypoglycemia, are dependent on the integrity of neuronal connections between the MBH and other hypothalamic and/or extrahypothalamic areas.
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Pituitary Stalk Portal Blood Collection in Rhesus Monkeys: Evidence for Pulsatile Release of Gonadotropin-Releasing Hormone (GnRH)
TL;DR: Data provide direct evidence for a hypothalamic mediation of pituitary LH pulsatile release in rhesus monkeys and showuctuations in portal blood GnRH were most prominent in ovariectomized animals, with peak levels of 200-800 pg/ml and intervals of 1 to 3 hours between pulses.
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Pulsatile patterns of gonadotropin release in subjects with and without ovarian function.
TL;DR: Minute-to-minute fluctuations of serum LH and FSH concentrations resembling a pulsatile pattern were demonstrated in both pre- and post-menopausal women, and a greater net increase of circulating LH was found in pulses during the midcycle surge which was more than double that seen during other phases of the cycle.
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Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man.
TL;DR: Assessment of the rates of disappearance of endogenous LH and HCG from serum following complete surgical hypophysectomy and removal of the placenta found that the disappearance rates appear to follow a double exponential curve although there may be a possible additional exponential.