Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome
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TLDR
The incidence of postoperative desaturation, respiratory failure, postoperative cardiac events, and ICU transfers was higher in patients with OSA, and a significant degree of heterogeneity of the effect among studies was found.Abstract:
Results. Thirteen studies were included in the final analysis (n¼3942). OSA was associated with significantly higher odds of any postoperative cardiac events [45/1195 (3.76%) vs 24/1420 (1.69%); odds ratio (OR) 2.07; 95% confidence interval (CI) 1.23‐3.50, P¼0.007] and ARF [33/ 1680 (1.96%) vs 24/3421 (0.70%); OR 2.43, 95% CI 1.34‐4.39, P¼0.003]. Effects were not heterogeneous for these outcomes (I 2 ¼0‐15%, P.0.3). OSA was also significantly associated with higher odds of desaturation [189/1764 (10.71%) vs 105/1881 (5.58%); OR 2.27, 95% CI 1.20‐4.26, P¼0.01] and ICU transfer [105/2062 (5.09%) vs 58/3681 (1.57%), respectively; OR 2.81, 95% CI 1.46‐5.43, P¼0.002]. Both outcomes showed a significant degree of heterogeneity of the effect among studies (I 2 ¼57‐68%, P,0.02). Subgroup analyses had similar conclusions as main analyses. Conclusions. The incidence of postoperative desaturation, respiratory failure, postoperativeread more
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