Patent
Method for preparation of polymer microparticles free of organic solvent traces
TLDR
In this paper, a method for the production of polymer microparticles in the absence of organic solvent is described. But the method is carried out in the presence of an organic solvent, and consists in the steps of combining first and second polymers, heating the combination obtained in step (a) so as to melt the first polymers; shaking the melted polymers obtained in stage (b) under conditions effective to produce a biphasic system.Abstract:
The present invention relates to a new method for the production of polymer microparticles The method is carried out in the absence of organic solvent, and consists in the steps of (a) combining first and second polymers, the first and second polymers being incompatible or immiscible, (b) heating the combination obtained in step (a) so as to melt the first and second polymers; (c) shaking the melted polymers obtained in step (b) under conditions effective to produce a biphasic system, the biphasic system comprising a dispersed phase and a matrix continuous phase, the dispersed phase consisting of a dispersion of the first polymer, the matrix continuous phase comprising the second polymer, the dispersed phase containing microparticles of the first polymer dispersed in the matrix continuous phase; (d) solidifying the biphasic system obtained in step (c) so as to keep the microparticles of the first polymer dispersed in the matrix continuous phase; and (e) separating and isolating the microparticles of the first polymer from the matrix continuous phase, wherein the first polymer in said dispersed phase is water-insoluble, while the second polymer forming the continuous phase is water-solubleread more
Citations
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Journal ArticleDOI
Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles.
TL;DR: Against the backdrop of an increasing number of new, poorly orally available drug entities entering development, microparticle delivery systems may be a viable strategy to rescue an otherwise undeliverable substance.
Patent
Process for preparing microparticles having a low residual solvent volume
Biggs Danielle,Heather Nettles +1 more
TL;DR: In this article, the disclosed processes for forming microparticles utilize low volumes of processing water while still providing micro-articles having low residual solvent levels, which is adaptable to both continuous and batch processes using oil/water or water/oil.
Patent
Microparticles and method for their production
TL;DR: In this article, a method for the synthesis of nano-or microparticles containing an active substance embedded in a polymer matrix is described. But the method for their production is not described.
Patent
Compositions and methods for delivery of poorly soluble drugs
TL;DR: In this article, the authors describe compositions comprising particles of poorly soluble drugs encapsulated by stabilizers, and methods of making such encapsulated particle compositions, and corresponding pharmaceutical compositions, as well as methods for making the corresponding formulations.
Journal ArticleDOI
A novel method for the preparation of retinoic acid-loaded nanoparticles.
TL;DR: The goal of present work was to investigate the use of bioerodible polymeric nanoparticles as carriers of retinoic acid (RA), which is known to induce differentiation of several cell lines into neurons.
References
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Book
Biodegradable polymers as drug delivery systems
Mark Chasin,Robert Langer +1 more
TL;DR: In this article, the properties, synthesis, and formulations of a number of well studied polymers increasingly being used in site-specific or systematic administration of pharmaceutical agents are reviewed and discussed.
Patent
Process for preparation of microspheres
TL;DR: In this paper, microspheres are prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier.
Patent
Preparation of multiwall polymeric microcapsules
TL;DR: In this article, a single step method for preparation of multi-layer polymeric delivery systems is described, in which two or three different degradable or non-degradable polymers which are not soluble in each other at a particular concentration, as dictated by their phase diagram, can be used.
Patent
Composite core coated microparticles and process of preparing same
TL;DR: In this article, a process for preparing coated microparticles, which process comprises preparing a solvent solution of an active ingredient to be encapsulated and a film-forming polymer, removing the solvent to provide a dry, composite, uniform admixture of the active ingredient and the polymer material, reducing the composite admixture to a defined smaller particle size distribution, coating the reduced composite core particles in a fluidized bed.
Patent
Polylactide drug mixtures for topical application atelet aggregation
TL;DR: In this paper, the authors present a formalization of the applicability of polyacetide and drug for topical application to the body as a film and provide a SLOW SUSTAINED RELEASE of the drug to the site.