Journal ArticleDOI
Methyl 2‐amino‐4‐(3‐fluorophenyl)‐4H‐benzo[h]chromene‐3‐carboxylate methanol solvate
TLDR
In this paper, the title compound, C21H16FNO3·CH3OH, was synthesized by the reaction of 1-naphthol with methyl cyanoacetate and 3-fluoro-benzaldehyde in methanol under microwave irradiation.Abstract:
The title compound, C21H16FNO3·CH3OH, was synthesized by the reaction of 1-naphthol with methyl cyanoacetate and 3-fluorobenzaldehyde in methanol under microwave irradiation. The pyran rings of the two independent molecules in the asymmetric unit adopt boat conformations. The crystal packing is stabilized by intermolecular N—H⋯O, O—H⋯O and C—H⋯π interactions.read more
Citations
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Design, synthesis, molecular docking, and biological evaluation of N -methyl-3-nitro-4-(nitromethyl)-4 H -chromen-2-amine derivatives as potential anti-cancer agents
A. Parthiban,Jayaraman Muthukumaran,A. Moushumi Priya,S. Jayachandran,Ramadas Krishna,H. Surya Prakash Rao +5 more
TL;DR: 4H-chromenes 8h and 8i exhibit promising anti-cancer properties and can be used as lead compounds for further development and evaluation of Lipinski and ADMET properties revealed their drug-like pharmacokinetic profiles.
Journal ArticleDOI
Design, synthesis, in vitro and in silico anti-cancer activity of 4H-chromenes with C4-active methine groups
A. Parthiban,M. Kumaravel,Jayaraman Muthukumaran,R. Rukkumani,Ramadas Krishna,H. Surya Prakash Rao +5 more
TL;DR: The findings show that the C4-malononitrile and C2-N-phenyl-substituted 4H-chromene are the most promising lead molecules for treatment of cancer.
Journal ArticleDOI
Dimethyl 2,2′-[(4-oxo-2-phenyl-4H-chromene-5,7-diyl)dioxy]diacetate: a more densely packed polymorph
TL;DR: The title molecule, C21H18O8, crystallizes in two crystal polymorphs, see also Nallasivam, Nethaji, Vembu & Jaswant [Acta Cryst. (2009), E65, o314–o315].
Journal ArticleDOI
2-Methyl-4-(naphthalen-2-yl)-3a-nitro-3,3a,4,9b-tetra-hydro-2H-spiro-[chromeno[3,4-c]pyrrole-1,3'-indolin]-2'-one.
Seenivasan Karthiga Devi,Thothadri Srinivasan,Jonnalagadda Naga Siva Rao,Raghavachary Raghunathan,Devadasan Velmurugan +4 more
TL;DR: In the title compound, C29H23N3O4, the 2-methylpyrrolidine ring adopts a twist conformation on the N—C bond involving the spiro C atom, while the hydropyran ring adopTS an envelope conformation with the methine C atom bonded to the O atom as the flap.
Journal ArticleDOI
6,8-Dichloro-N-methyl-3-nitro-4-nitro-methyl-4H-chromen-2-amine.
TL;DR: In the title compound, C11H9Cl2N3O5, the dihydropyran ring adopts a near-half-chair conformation and the molecular structure displays an S(6) motif formed by intramolecular N—H⋯O hydrogen bonding.
References
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A semi-empirical method of absorption correction
TL;DR: An extension of Furnas's method is described in this paper, where the variation of intensity of an axial reflection as the crystal is rotated about the goniometer axis is used to give a curve of relative transmission T against azimuthal angle ϕ for the corresponding reciprocal lattice level.