Book ChapterDOI
Microbial models for drug metabolism.
TLDR
Emphasis is laid on the potential for selected microorganisms to mimic all patterns of mammalian biotransformations and to provide preparative methods for structural identification and toxicological and pharmacological studies of drug metabolites.Abstract:
This review describes microbial transformation studies of drugs, comparing them with the corresponding metabolism in animal systems, and providing technical methods for developing microbial models. Emphasis is laid on the potential for selected microorganisms to mimic all patterns of mammalian biotransformations and to provide preparative methods for structural identification and toxicological and pharmacological studies of drug metabolites.read more
Citations
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Journal ArticleDOI
Practical issues in the application of oxygenases
TL;DR: Various issues in biocatalysis using oxygenases, such as screening strategies, overoxidation, uncoupling, substrate uptake, substrate toxicity, and oxygen mass transfer are reviewed.
Book ChapterDOI
Fluoroquinolone Antibiotics in the Environment
Premasis Sukul,Michael Spiteller +1 more
TL;DR: Fluoroquinolones bind strongly to topsoil, reducing the threat of surface water and groundwater contamination and explains the recalcitrance of FQs.
Journal ArticleDOI
Cunninghamella--a microbial model for drug metabolism studies--a review.
Sepuri Asha,M. Vidyavathi +1 more
TL;DR: Emphasis is laid on the potential of Cunninghamella fungus to mimic mammalian drug biotransformations and to use as in vitro model for drug metabolism studies and for further toxicological and pharmacological studies of metabolites.
Journal ArticleDOI
A critical review on exploiting the pharmaceutical potential of plant endophytic fungi.
TL;DR: How advanced chemical, biotechnological and computational molecular biology methods can be used for robust exploitation of bioactive compounds from these microorganisms is focused on.
Journal ArticleDOI
Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.
TL;DR: Bristol Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08534, Bristol-Myers SquibB, Pharmaceutical research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, is contacting you for information on drug discovery and development.
References
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Journal ArticleDOI
Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
TL;DR: Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
Book
Biotransformations in Organic Chemistry
TL;DR: This professional referencebook on Biotransformations in organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
BookDOI
Enzyme Catalysis in Organic Synthesis
Karlheinz Drauz,Herbert Waldmann +1 more
TL;DR: Extended applications of Enzymatic Catalytic Promiscuity and the Design of New Enzyme Catalyzed ReactionsCatalytic Antibodies Chemoenzymatic Dynamic Kinetic Resolution and Related Dynamic Asymmetric Transformations Biocatalysis in Material Science Industrial Applications of EnZymes in Emerging Areas.
Book
Enzymes in synthetic organic chemistry
TL;DR: Part 1 general aspects: rate acceleration in enzyme-catalyzed reactions Michaelis-Menten kinetics enzyme inhibition specificity improvement or alteration of enzyme specifity enzyme stabilization and reactor configuration cofactor regeneration enzyme catalysis in organic solvents multienzyme systems and metabolic engineering rational design of new enzymatic catalysts references.
Journal ArticleDOI
Human P450 metabolism of warfarin.
TL;DR: The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially metabolized by human cytochromes P450 (CYP) and is affected primarily when metabolism of S-warfarin is altered.
Related Papers (5)
Microbial models of mammalian metabolism of xenobiotics: An updated review.
Cunninghamella--a microbial model for drug metabolism studies--a review.
Sepuri Asha,M. Vidyavathi +1 more