Minoxidil and its use in hair disorders: a review.
TLDR
This article aims to review and update current information on the pharmacology, mechanism of action, clinical efficacy, and adverse events of topical minoxidil.Abstract:
Minoxidil was first introduced as an antihypertensive medication and the discovery of its common adverse event, hypertrichosis, led to the development of a topical formulation for promoting hair growth. To date, topical minoxidil is the mainstay treatment for androgenetic alopecia and is used as an off-label treatment for other hair loss conditions. Despite its widespread application, the exact mechanism of action of minoxidil is still not fully understood. In this article, we aim to review and update current information on the pharmacology, mechanism of action, clinical efficacy, and adverse events of topical minoxidil.read more
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Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration.
Dae Hyun Ha,Hyun Keun Kim,Joon Lee,Hyuck Hoon Kwon,Gyeong Hun Park,Steve Hoseong Yang,Jae-Yoon Jung,Hosung Choi,Junho Lee,Sumi Sung,Yong Weon Yi,Byong Seung Cho +11 more
TL;DR: This review highlights recent studies that investigate therapeutic potential of MSC-exosomes and relevant mode of actions for skin diseases, as well as quality control measures required for development of exosome-derived therapeutics.
Iconography : Alopecia areata : An appraisal of new treatment approaches and overview of current therapies
Lauren C. Strazzulla,Eddy Hsi Chun Wang,Lorena Avila,Kristen Lo Sicco,Nooshin Brinster,Angela M. Christiano,Jerry Shapiro +6 more
TL;DR: In this article, the authors evaluated the evidence concerning the efficacy, side effects, and durability of the Janus kinase inhibitors for the treatment of alopecia areata.
Journal ArticleDOI
Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals
TL;DR: The use of hormonal and non-hormonal compounds are suggested, which—based on their mechanism of action—could be used in these cases depending on clients’ requests.
Journal ArticleDOI
Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.
TL;DR: Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in hair loss, that affects up to 2% of the general population as discussed by the authors, while the exact pathobiology of AA has still remained elusive, while the common theory is the collapse of the immune privilege of the hair follicle caused by immunological mechanism.
Journal ArticleDOI
Role of janus kinase inhibitors in the treatment of alopecia areata.
TL;DR: Evidence of the efficacy and safety of JAKis in the treatment of AA is summarized and improvement is required in topical forms of tofacitinib and ruxolitinib.
References
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TL;DR: Nicotine, psychotropic drugs, and silicone implants are 3 important topics reviewed in this statement that are important to protect nursing infants from untoward effects of maternal medication but also to allow effective pharmacologic treatment of breastfeeding mothers.
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Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models.
Biana Godin,Elka Touitou +1 more
TL;DR: Work from in vitro permeation studies to clinical performance is reviewed, presenting various experimental models used in dermal/transdermal research, including the use of excised human or animal skin, cultured skin equivalents and animals.
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Control of hair growth and follicle size by VEGF-mediated angiogenesis
TL;DR: These results identify VEGF as a major mediator of hair follicle growth and cycling and provide the first direct evidence that improved follicle vascularization promotes hair growth and increases hair follicles and hair size.
Journal ArticleDOI
Minoxidil: mechanisms of action on hair growth
Andrew G. Messenger,J. Rundegren +1 more
TL;DR: The current state of knowledge on the mode of action of minoxidil on hair growth is reviewed, and lines of future research are indicated that may be relevant to hair growth.
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