Book ChapterDOI
Mitochondria and apoptosis: new therapeutic targets.
David M. Hockenbery,Christopher D. Giedt,Jason W. O'Neill,Michael Keoni Manion,Deborah E. Banker +4 more
About:
This article is published in Advances in Cancer Research.The article was published on 2002-01-01. It has received 112 citations till now. The article focuses on the topics: Bcl-2 Homologous Antagonist-Killer Protein & Bcl-2-associated X protein.read more
Citations
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Journal ArticleDOI
Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
Journal ArticleDOI
Mitochondrial glutathione, a key survival antioxidant.
Montserrat Marí,Albert Morales,Anna Colell,Carmen García-Ruiz,José C. Fernández-Checa,José C. Fernández-Checa +5 more
TL;DR: From the evaluation ofmGSH influence on different pathologic settings such as hypoxia, ischemia/reperfusion injury, aging, liver diseases, and neurologic disorders, it is becoming evident that it has an important role in the pathophysiology and biomedical strategies aimed to boost mGSH levels.
Journal ArticleDOI
Surface exposure of phosphatidylserine in pathological cells.
TL;DR: This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal.
Journal ArticleDOI
Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity
TL;DR: NRTls can block both HIV reverse transcriptase and mitochondrial DNA polymerase gamma, and inhibition of the latter enzyme is the most likely cause of the adverse effects associated with these drugs.
Journal ArticleDOI
Mitochondrial DNA mutations in human cancer.
TL;DR: A detailed summary of mtDNA mutations that have been reported in various types of cancer is provided and some perspective is offered as to the origin of these of mutations, their functional consequences in cancer development, and possible therapeutic implications.
References
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Journal ArticleDOI
Caspases: Enemies Within
TL;DR: This work has shown that understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
Journal ArticleDOI
Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
Journal ArticleDOI
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Jie Yang,Xuesong Liu,Xuesong Liu,Kapil N. Bhalla,Caryn Naekyung Kim,Ana Maria Ibrado,Jiyang Cai,Tsung I. Peng,Dean P. Jones,Xiaodong Wang,Xiaodong Wang +10 more
TL;DR: One possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria, which is normally located in the mitochondrial intermembrane space.