Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases.
Siarhei A. Dabravolski,Evgeny E. Bezsonov,Mirza S. Baig,Tatyana V. Popkova,Alexander N. Orekhov +4 more
TLDR
In this article, a review of recent genetic evidence, proving the diverse nature of metabolic pathways involved in NAFLD pathogenesis, is presented, concluding that the altered operation of fatty acid β-oxidation in liver mitochondria is the key process, connecting NASD-mediated dyslipidemia and elevated CVD risk.Abstract:
The prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem, affecting a huge population around the globe. However, CVDs (cardiovascular diseases) are the most common cause of mortality in NAFLD patients. Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense LDL (low-density lipoprotein) particles, and decreased HDL-C (high-density lipoprotein cholesterol) levels, is often observed in NAFLD patients. In this review, we summarize recent genetic evidence, proving the diverse nature of metabolic pathways involved in NAFLD pathogenesis. Analysis of available genetic data suggests that the altered operation of fatty-acid β-oxidation in liver mitochondria is the key process, connecting NAFLD-mediated dyslipidemia and elevated CVD risk. In addition, we discuss several NAFLD-associated genes with documented anti-atherosclerotic or cardioprotective effects, and current pharmaceutical strategies focused on both NAFLD treatment and reduction of CVD risk.read more
Citations
More filters
Journal ArticleDOI
Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases.
TL;DR: In this paper, a review summarizes the evidence linking obesity with metabolic dysfunction-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), hypertension, cardiovascular disease (CVD), autoimmune diseases, and some cancers, CVD being one of the main causes of death in the world.
Journal ArticleDOI
Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
Rossella Doria,Valentina Annamaria Genchi,Cristina Caccioppoli,Isabella Calderoni,Nicola Marrano,Giuseppina Biondi,Anna Borrelli,Ludovico Di Gioia,Francesco Giorgino,Luigi Laviola +9 more
TL;DR: In this article , a review summarizes data relating to the contribution of the main adipose tissue depots, including both remote (i.e., intra-abdominal, hepatic, skeletal, pancreatic, renal, and mesenteric adipose locations, on the cardiovascular system.
Journal ArticleDOI
Pathophysiological mechanisms of cardiovascular disorders in non-alcoholic fatty liver disease
TL;DR: This review focuses on potential pathophysiological mechanisms of cardiovascular disorders in non-alcoholic fatty liver that may include systemic low-grade inflammation, atherogenic dyslipidemia, abnormal glucose metabolism and hepatic insulin resistance, endothelial dysfunction, gut dysbiosis, as well as the associated cardiac remodeling.
Book ChapterDOI
Frizzled receptors and SFRP5 in lipid metabolism: Current findings and potential applications.
Dinh-Toi Chu,Thanh-Lam Nguyen +1 more
TL;DR: In this paper , secreted Frizzled Related Protein 5 (SFRP5) andFrizzled receptors (FZD) are two newly discovered adipokines that are involved in lipid metabolism as well as lipogenesis.
Journal ArticleDOI
A high-fat diet increases hepatic mitochondrial turnover through restricted acetylation in a NAFLD mouse model.
Mirjavid Aghayev,Andrea Arias-Alvarado,Serguei Ilchenko,Josephine K Lepp,Iain Scott,Yeong Renn Chen,Guo-Fang Zhang,Tsung-Heng Tsai,Takhar Kasumov +8 more
TL;DR: In this article , the effect of high-fat diet (HFD)-induced altered acetylation in protein turnover in LDL receptor-deficient (LDLR-/-) mice susceptible to diet-induced non-alcoholic fatty liver disease (NAFLD).
References
More filters
Journal ArticleDOI
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
Khoa D. Nguyen,Yifu Qiu,Xiaojin Cui,Y. P. Sharon Goh,Y. P. Sharon Goh,Julia W. Mwangi,Tovo David,Lata Mukundan,Frank Brombacher,Richard M. Locksley,Ajay Chawla +10 more
TL;DR: A role for alternatively activated macrophages is discovered in the orchestration of an important mammalian stress response, the response to cold, as reported in mice.
Journal ArticleDOI
Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease.
TL;DR: The most recent findings on the inter-organ signaling and interplay with the gut microbiota of bile acids and their receptors in meta-inflammation are discussed, with a focus on their pathophysiologic roles in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic steatohepatitis, and their potential therapeutic applications.
Journal ArticleDOI
The changing landscape of atherosclerosis.
TL;DR: In this article, the authors review the evidence and discuss its implications for understanding of atherosclerosis, and examine its implications in the treatment of cardiovascular disease. But they do not discuss the role of the bone marrow in the pathogenesis of the disease.
Journal ArticleDOI
Understanding the Physiology of FGF21
TL;DR: The biology of FGF21 is intrinsically complicated owing to its diverse metabolic functions in multiple target organs and its ability to act as an autocrine, paracrine, and endocrine factor.
Journal ArticleDOI
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress POTENTIAL ROLE IN FRUCTOSE-DEPENDENT AND -INDEPENDENT FATTY LIVER
Miguel A. Lanaspa,Laura G. Sánchez-Lozada,Yea Jin Choi,Christina Cicerchi,Mehmet Kanbay,Carlos A. Roncal-Jimenez,Takuji Ishimoto,Nanxing Li,George Marek,Murat Duranay,George F. Schreiner,Bernardo Rodriguez-Iturbe,Takahiko Nakagawa,Duk Hee Kang,Yuri Y. Sautin,Richard J. Johnson +15 more
TL;DR: It is shown that fructose also stimulates triglyceride synthesis via a purine-degrading pathway that is triggered from the rapid phosphorylation of fructose by fructokinase, which provides new insights into the pathogenesis of hepatic fat accumulation under normal and diseased states.