Modification of in vitro cytotoxicity of lymphocytes from patients with chronic ulcerative colitis or granulomatous colitis for allogenic colonic epithelial cells.
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TLDR
It is speculated that the E. coli extract could be a specific antigen and that its preincubation with sensitized lymphocytes resulted in their desensitization, and if this view were correct, then the phenomenon of cytotoxicity for colonic cells might be a final expression of delayed hypersensitivity in vitro, but the arguments against this are reviewed and presently it remains highly theoretical.About:Â
This article is published in Gastroenterology.The article was published on 1970-05-01 and is currently open access. It has received 45 citations till now. The article focuses on the topics: Delayed hypersensitivity & Antigen.read more
Citations
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Journal ArticleDOI
Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial.
TL;DR: The results suggest that treatment with a non-pathogenic E. coli has an equivalent effect to mesalazine in maintaining remission of ulcerative colitis.
Journal ArticleDOI
Inflammatory bowel disease: the surgical pathology of Crohn's disease and ulcerative colitis.
Ashley B. Price,Basil C. Morson +1 more
TL;DR: Immunologic studies are still confusing, but it is suggested that patients with ulcerative colitis and Crohn's disease may have a state of altered immunologic reactivity.
Journal ArticleDOI
Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis
F Takahashi,K M Das +1 more
TL;DR: It is suggested that the 40-kD protein is a colonic "autoantigen" that may initiate a specific IgG antibody response in UC and it appeared to be organ specific.
Journal Article
Comparative mapping of the local distribution of immunoglobulin-containing cells in ulcerative colitis and Crohn's disease of the colon.
K Baklien,P Brandtzaeg +1 more
TL;DR: The pronounced local humoral immune response, particularly that involving IgG, might be of pathogenetic importance by aggravating and perpetuating in the inflammatory bowel disease.
Journal ArticleDOI
A working hypothesis for the etiology and pathogenesis of nonspecific inflammatory bowel disease
TL;DR: It is suggested that inflammatory bowel disease (IBD) results from the establishment of a state of hypersensitivity to antigen(s) of bacteria normally present in the individual's gastrointestinal tract and that the pathologic and clinical features of IBD then result from a predominantly cell-mediated hypersensitivity reaction in the bowel wall.
References
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Journal ArticleDOI
Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity
Barry R. Bloom,Boyce Bennett +1 more
TL;DR: The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied and elaborated into the medium a soluble material capable of inhibiting migration of normal exudates.
Journal ArticleDOI
Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.
TL;DR: It is demonstrated that, following incubation of sensitive lymphoid cells with specific antigen for 24 hr, a nondialyzable substance is detected in the cell-free supernatants which inhibits the migration of normal peritoneal cells.
Journal ArticleDOI
Release of lipopolysaccharide by EDTA treatment of E. coli.
TL;DR: This treatment of E. coli with ethylenediaminetetraacetate which causes an increase in permeability also results in the rapid release of 35 to 50% of the cell wall lipopolysaccharide and may be a useful tool in the isolation of chemically pure lipopoly Saccharide.
Journal ArticleDOI
In vitro studies of ulcerative colitis. II. Cytotoxic action of white blood cells from patients on human fetal colon cells.
Peter Perlmann,Ove Broberger +1 more
TL;DR: The cytotoxic action of the patients' white cells was immunologically specific, since no difference from the controls was found in the isotope release when cells from other organs or animals were similarly treated.
Journal ArticleDOI
Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity
Nancy H. Ruddle,Byron H. Waksman +1 more
TL;DR: Lymph node cells from inbred rats having delayed sensitivity to soluble proteins inhibit growth of syngeneic or allogeneic fibroblasts in the presence of specific antigen.
Related Papers (5)
In vitro studies of ulcerative colitis. II. Cytotoxic action of white blood cells from patients on human fetal colon cells.
Peter Perlmann,Ove Broberger +1 more
Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells.
In vitro studies of ulcerative colitis : i. reactions of patients' serum with human fetal colon cells in tissue cultures
Ove Broberger,Peter Perlmann +1 more