Journal ArticleDOI
Modulation of the GABA receptor complex by a steroid anaesthetic.
TLDR
It is suggested that alphaxalone and pentobarbitone share a common mode of action on the GABA system, which may be relevant to the mechanisms by which these drugs produce anaesthesia.About:
This article is published in Brain Research.The article was published on 1984-12-10. It has received 484 citations till now. The article focuses on the topics: Muscimol & GABA receptor complex.read more
Citations
More filters
Journal ArticleDOI
Steroid Hormone Metabolites are Barbiturate-Like Modulators of the GABA Receptor
Maria Dorota Majewska,Neil L. Harrison,Rochelle D. Schwartz,Jeffery L. Barker,Steven M. Paul +4 more
TL;DR: Two metabolites of the steroid hormones progesterone and deoxycorticosterone are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons, which may explain the ability of certain steroid hormones to rapidly alter neuronal excitability.
Journal ArticleDOI
Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance.
TL;DR: The abundant CNS cholesterol and its sulfate derivative serve as precursors of different neurosteroids, which bidirectionally modulate neuronal excitability, by potentiating or inhibiting function of the GABAA receptors.
Journal ArticleDOI
Neurosteroids: endogenous regulators of the GABAA receptor
Delia Belelli,Jeremy J. Lambert +1 more
TL;DR: GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs.
Journal ArticleDOI
Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators
TL;DR: This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.
Journal ArticleDOI
Neurosteroids and GABAA receptor function
TL;DR: Recent advances in this field are reviewed and the therapeutic potential of this novel, non-genomic effect of steroids is discussed and whether they may influence behaviour under physiological, or pathophysiological, conditions is investigated.
References
More filters
Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
Journal ArticleDOI
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
TL;DR: The results suggest that reduction of synaptic excitation mediated via NMA receptors contributes to the anaesthetic/analgesic properties of these two dissociative anaesthetics.
Journal ArticleDOI
3 H-baclofen and 3 H-GABA bind to bicuculline-insensitive GABA B sites in rat brain
D. R. Hill,N. G. Bowery +1 more
TL;DR: It is reported that high-affinity saturable binding of 3H-baclof en and3H-G AB A to the GABAB site can be detected in fragments of crude synaptic membranes prepared from rat brain and that GABA and baclofen can compete for the same recognition site.
Journal ArticleDOI
Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system.
TL;DR: Gamma-aminobutyric acid binds to synaptic membrane fractions of rat brain in a selective fashion representing an interaction with postsynaptic GABA receptors, with intermediate values in the thalamus, hippocampus, hypothalamus, cerebral cortex, midbrain, and corpus striatum.