Molecular characterization of an operon required for pertussis toxin secretion
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TLDR
A set of accessory proteins are most likely involved in the secretion of pertussis toxin, and these proteins appear to be members of a family of proteins involved inThe secretion of macromolecules from bacteria.Abstract:Â
Mutants of Bordetella pertussis which are defective in secretion of pertussis toxin were isolated and characterized. The region of the B. pertussis chromosome identified by mutagenesis as playing a role in transport of pertussis toxin was sequenced. Analysis of this region revealed eight open reading frames, seven of which predict a protein exhibiting homology with one of the VirB proteins of Agrobacterium tumefaciens, which are involved in the transport of the T-DNA molecule across bacterial and plant membranes. Thus a set of accessory proteins are most likely involved in the secretion of pertussis toxin, and these proteins appear to be members of a family of proteins involved in the secretion of macromolecules from bacteria.read more
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Journal ArticleDOI
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.
Stefano Censini,Christina Lange,Z Xiang,Jean E. Crabtree,P. Ghiara,Mark Borodovsky,Rino Rappuoli,Antonello Covacci +7 more
TL;DR: The cag region may encode a novel H. pylori secretion system for the export of virulence determinants and Transposon inactivation of several of the cagI genes abolishes induction of IL-8 expression in gastric epithelial cell lines.
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors (secretionyinsertion sequenceyinflammationyevolution)
TL;DR: The locus that contains cagA (cag) is part of a 40-kb DNA insertion that likely was acquired horizontally and integrated into the chromosomal glutamateracemasegene.
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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies
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TL;DR: DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussedis.
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Conjugative Transfer by the Virulence System of Legionella pneumophila
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Biological Diversity of Prokaryotic Type IV Secretion Systems
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