Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies
Seema Mattoo,Jonathan D. Cherry +1 more
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TLDR
DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussedis.Abstract:
Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines.read more
Citations
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Recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: These revised recommendations by the Advisory Committee on Immunization Practices concerning prevention of plague update previous recommendations (MMWR 1982;31:301-4).
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Bioaerosols in the Earth system: Climate, health, and ecosystem interactions
Janine Fröhlich-Nowoisky,Christopher J. Kampf,Christopher J. Kampf,Bettina Weber,J. Alex Huffman,Christopher Pöhlker,Meinrat O. Andreae,Naama Lang-Yona,Susannah M. Burrows,Sachin S. Gunthe,W. Elbert,Hang Su,Peter Hoor,Eckhard Thines,Thorsten Hoffmann,Viviane R. Després,Ulrich Pöschl +16 more
TL;DR: A review of the state of bioaerosol research, highlights recent advances, and outlines future perspectives in terms of identification, characterization, transport and transformation processes, as well as their interactions with climate, health, and ecosystems, focusing on the role bio-aerosols play in the Earth system.
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A fully integrated microfluidic genetic analysis system with sample-in–answer-out capability
Christopher J. Easley,James M. Karlinsey,Joan M. Bienvenue,Lindsay A. Legendre,Michael G. Roper,Sanford H. Feldman,Molly A. Hughes,Erik L. Hewlett,Tod J. Merkel,Jerome P. Ferrance,James P. Landers,James P. Landers +11 more
TL;DR: A microfluidic genetic analysis system that represents a previously undescribed integrated microfluidity device capable of accepting whole blood as a crude biological sample with the endpoint generation of a genetic profile is described.
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Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
TL;DR: The observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis and suggests that optimal control of pertussedis will require the development of improved vaccines.
Journal Article
Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP).
Karen R. Broder,Margaret M. Cortese,John K. Iskander,Katrina Kretsinger,Barbara A. Slade,Kristin Brown,Christina M Mijalski,Tejpratap S P Tiwari,Emily J Weston,Amanda C. Cohn,Pamela U. Srivastava,John S. Moran,Benjamin Schwartz,Trudy V. Murphy +13 more
TL;DR: Adolescents aged 11-18 years should receive a single dose of Tdap instead of tetanus and diphtheria toxoids vaccine (Td) for booster immunization against tetanus, diphTheria, and pertussis if they have completed the recommended childhood DTP/DTaP vaccination series.
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