Journal ArticleDOI
Molecular-Cloning of the Human Gene Encoding Lanosterol Synthase from a Liver cDNA Library
TLDR
The cloning and characterization of the human gene (OSC) encoding lanosterol synthase, a predicted 83 kDa protein of 732 amino acids, is reported herein, and the deduced amino acid sequence is 36-40% identical to known yeast and plant homologues and 83% similar to Rattus norvegicus lanosterl synthase.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1995-08-01. It has received 75 citations till now. The article focuses on the topics: Lanosterol synthase & Lanosterol.read more
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On the origins of triterpenoid skeletal diversity.
TL;DR: The triterpenoids are a large group of natural products derived from C(30) precursors and each of these structures is classified and mechanisms for their formation are provided.
Journal ArticleDOI
Malformation syndromes caused by disorders of cholesterol synthesis
Forbes D. Porter,Gail E. Herman +1 more
TL;DR: In this paper, the authors reviewed clinical and basic science aspects of Smith-Lemli-Opitz syndrome, desmosterolosis, lathosterolosis and HEM dysplasia.
Journal ArticleDOI
Enzyme Mechanisms for Polycyclic Triterpene Formation.
TL;DR: It can be concluded that the role of the oxidosqualene cyclases involves protection of the intermediate carbocation against addition of water or deprotonation by base, thereby allowing the shift of the hydride and methyl groups along a thermodynamically and kinetically favorable cascade.
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Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications
Bharat Singh,R. A. Sharma +1 more
TL;DR: In this review paper, recent developments in the biosynthesis of terpenoids, indepth description of terpene synthases and their phylogenetic analysis, regulation of ter pene biosynthesis as well as updates of ter penes which have entered in the clinical studies are reviewed thoroughly.
Thematic Review Series: Genetics of Human Lipid Diseases Malformation syndromes caused by disorders of cholesterol synthesis
TL;DR: Clinical and basic science aspects of Smith-Lemli-Opitz syndrome, desmosterolosis, lathosterolosis), HEM dysplasia, X-linked dominant chondrodysplasia punctata, Congenital Hemidyspl Asia with Ichthyosiform erythroderma and Limb Defects Syndrome, sterol-C-4 methyloxidase-like deficiency, and Antley-Bixler syndrome are reviewed.