Journal ArticleDOI
MR lymphangiography: imaging strategies to optimize the imaging of lymph nodes with ferumoxtran-10.
Mukesh G. Harisinghani,W. Thomas Dixon,Mansi A. Saksena,Elena F. Brachtel,Daniel J. Blezek,Paritosh Jayant Dhawale,Maha Torabi,Peter F. Hahn +7 more
TLDR
MR imaging performed before and after administration of ferumoxtran-10 allows presurgical mapping of lymph nodes and quantitative estimation of T2*-weighted sequences and should be considered to optimize acquisition strategies.Abstract:
Detection of local or regional metastases to lymph nodes is clinically important in virtually any type of primary tumor. Current imaging techniques rely heavily on the size criterion for characterization of nodal disease. However, size can be an ineffective parameter for diagnosis of tumor spread to lymph nodes. Magnetic resonance (MR) imaging performed before and after administration of ferumoxtran-10 is a promising technique for characterization of lymph nodes in patients with various primary tumors. Normal homogeneous uptake of ferumoxtran-10 in nonmetastatic nodes shortens the T2 and T2*, turning these nodes dark, whereas malignant nodes lack uptake and remain hyperintense. To optimize acquisition strategies, the following factors should be considered: the timing of contrast material–enhanced imaging, the section thickness, the imaging plane, and the imaging parameters for T2*-weighted sequences. In addition, MR imaging with ferumoxtran-10 allows presurgical mapping of lymph nodes and quantitative est...read more
Citations
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Journal ArticleDOI
Recent advances in iron oxide nanocrystal technology for medical imaging
TL;DR: Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models.
Journal ArticleDOI
Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis
O. C. C. Will,Sanjay Purkayastha,Christopher L. Chan,Thanos Athanasiou,Ara Darzi,Wady Gedroyc,Paris P. Tekkis +6 more
TL;DR: Ferumoxtran-10-enhanced MRI is sensitive and specific in detection of lymph-node metastases for various tumours, and allows functional and anatomical definition when used as an imaging modality.
Journal Article
Diagnosis and Treatment of Venous Malformations. Consensus Document of the International Union of Phlebology (IUP): updated 2013
Byung-Boong Lee,Iris Baumgartner,P Berlien,G Bianchini,P Burrows,Peter Gloviczki,Y Huang,James Laredo,D A Loose,Jovan N. Markovic,R Mattassi,Kurosh Parsi,Eberhard Rabe,M Rosenblatt,Cynthia K. Shortell,F Stillo,M Vaghi,L Villavicencio,Paolo Zamboni +18 more
TL;DR: The definition and classification of VMs were strengthened with the addition of angiographic data that determines the hemodynamic characteristics, the anatomical pattern of draining veins and hence the risk of complication following sclerotherapy and a "modified" Hamburg classification was adopted.
Journal ArticleDOI
Combined Ultrasmall Superparamagnetic Particles of Iron Oxide–Enhanced and Diffusion-Weighted Magnetic Resonance Imaging Reliably Detect Pelvic Lymph Node Metastases in Normal-Sized Nodes of Bladder and Prostate Cancer Patients
Harriet C. Thoeny,Maria Triantafyllou,Frederic D. Birkhaeuser,Johannes M. Froehlich,Dechen W. Tshering,Tobias Binser,Achim Fleischmann,Peter Vermathen,Urs E. Studer +8 more
TL;DR: USPIO-DW-MRI is a fast and accurate method for detecting pelvic lymph node metastases, even in normal-sized nodes of bladder or prostate cancer patients.
Journal ArticleDOI
Muscle-Invasive Urothelial Carcinoma of the Bladder
S. Bruce Malkowicz,Hendrik Van Poppel,Gerald H. Mickisch,Vito Pansadoro,Joachim W. Thüroff,Mark S. Soloway,Sam S. Chang,Mitchell C. Benson,Iwao Fukui +8 more
TL;DR: No tumor markers have been prospectively validated to help guide clinical decision making, and prospective trials incorporating marker data should be encouraged.
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Journal ArticleDOI
Evaluation of Neck and Body Metastases to Nodes with Ferumoxtran 10–enhanced MR Imaging: Phase III Safety and Efficacy Study
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