Journal ArticleDOI
Multiple infections in cases of cervical cancer from a high-incidence area in tropical Africa.
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TLDR
A linear trend in the rise of risk for cervical cancer was noted with increasing number of infections, and HSV and CMV were associated with cervical cancer only when infection by both of these agents was demonstrable.Abstract:
The presence of several infections was determined in tissue and serum samples from 34 cases and 23 controls seen in 1984-85 at Mulago Hospital in Kampala, Uganda. When assessing single infections, association with cervical cancer could be shown for 5 agents, namely by Southern blot assay for human papillomavirus types 16 and 18 (HPV), and by serological tests at varying levels of antibody titres, for herpes simplex virus type I and/or 2 (HSV), cytomegalovirus (CMV), Epstein-Barr virus, viral capsid antigen (EBV-VCA), and Chlamydia trachomatis (CLT). Due to interaction, HSV and CMV were associated with cervical cancer only when infection by both of these agents was demonstrable. In the assessment of the simultaneous presence of these 5 infections, moderately high antibody titres were taken as the cut-off point for infection by HSV, CMV, EBV-VCA, and CLT. This showed that 3 and 4 infections at a time were seen in the majority of the cases in contrast to the controls with essentially no more than 2 such infections. A linear trend in the rise of risk for cervical cancer was noted with increasing number of infections.read more
Citations
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Journal ArticleDOI
The causal link between human papillomavirus and invasive cervical cancer: A population-based case-control study in colombia and spain
Nubia Muñoz,F. X. Bosch,S de Sanjosé,Luis Alberto Tafur,Isabel Izarzugaza,Miguel Gili,P. Viladiu,Carmen Navarro,C. Martos,Nieves Ascunce,L. C. Gonzalez,John M. Kaldor,E. Guerrero,Attila T. Lorincz,M. Santamaria,P. Alonso De Ruiz,Nubia Aristizabal,Keerti V. Shah +17 more
TL;DR: There is a very strong association between HPV 16, 18, 31, 33 and 35 and invasive cervical cancer and that this association is probably causal.
Journal ArticleDOI
Health consequences of child marriage in Africa.
TL;DR: Comprehensive, multifaceted policies are needed to end child marriage and protect girls and their offspring.
Journal ArticleDOI
The epidemiology of cervical carcinogenesis.
Mark Schiffman,Louise A. Brinton +1 more
TL;DR: The steps in cervical carcinogenesis appear to be fundamentally the same everywhere, with a central role for HPV infection, however, the importance of etiologic cofactors like smoking may vary by region.
Journal ArticleDOI
Cancer in Kampala, Uganda, in 1989–91: Changes in incidence in the era of aids
TL;DR: The most striking feature is the emergence of Kaposi's sarcoma as the leading cancer in males and the second most frequent in females, which parallels the evolution of the epidemic of AIDS.
Journal ArticleDOI
Risk factors for cervical cancer in Colombia and Spain
F. X. Bosch,Nubia Muñoz,S de Sanjosé,Isabel Izarzugaza,Miguel Gili,P. Viladiu,María José Tormo,Pilar Moreo,Nieves Ascunce,L. C. Gonzalez,Luis Alberto Tafur,John M. Kaldor,E. Guerrero,Nubia Aristizabal,M. Santamaria,P. Alonso De Ruiz,Keerti V. Shah +16 more
TL;DR: A population‐based case‐control study of cervical cancer was conducted in Spain and Colombia to assess the relationship between cervical cancer and exposure to human papillomavirus (HPV), selected aspects of sexual and reproductive behaviour, use of oral contraceptives, screening practices and smoking.
References
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Journal ArticleDOI
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Tests for Linear Trends in Proportions and Frequencies
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A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.
TL;DR: DNA of a new papillomavirus type was cloned from a cervical carcinoma biopsy and the data reveal that the DNA might be integrated into the host cell genome, which is tentatively proposed to be HPV 18.
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Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events?
TL;DR: The model reconciles seroepidemiological data linking HSV to human genital cancer with the apparent difficulties in finding HSV DNA by biopsy in genital cancer.