Open AccessJournal Article
Multiple sclerosis: disturbed kappa:lambda chain ratio of immunoglobulin g in cerebrospinal fluid
H. Link,O. Zettervall +1 more
TLDR
Abnormal kappa:lambdachain ratios were found in patients with multiple sclerosis, butinavariety of other neurological disorders, but the increase inratio wasaproperty of immunoglobulin G.Abstract:
SUMMARY Abnormal kappa:lambdachain ratios werefoundincerebrospinal fluid from somepatients withmultiple sclerosis, butnotinavariety ofother neurological disorders. Theincrease inratio wasaproperty ofimmunoglobulin G.read more
Citations
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Journal ArticleDOI
Immunoglobulins in multiple sclerosis and infections of the nervous system.
Hans Link,Ragnar Müller +1 more
TL;DR: Oligoclonal CSF-immunoglobulin G in the form of discrete bands on agar gel electrophoresis and abnormal kappa:lambda immunoglobulus light chain ratio was found in 94% and 53% in MS, in 39% and 0% in CNS infections, and in 3% and 3% in other neurological disorders.
Journal ArticleDOI
Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis
Birgit Obermeier,Birgit Obermeier,Reinhard Mentele,Joachim Malotka,Josef Kellermann,Tania Kümpfel,Hartmut Wekerle,Friedrich Lottspeich,R. Hohlfeld,R. Hohlfeld,Klaus Dornmair,Klaus Dornmair +11 more
TL;DR: Compared the Ig transcriptomes of B cells with the corresponding Ig proteomes in CSF samples from four subjects with multiple sclerosis, it is shown that CSF B cells indeed produce the oligoclonal Ig bands.
Journal ArticleDOI
Deficit of suppressor T cells in active multiple sclerosis.
Marie-Anne Bach,Elizabeth Tournier,Francoise Phan-Dinh-Tuy,Lucienne Chatenoud,Jean-François Bach,Claude Martin,Jean-Denis Degos +6 more
TL;DR: Suppressor T cells in forty-seven patients with multiple sclerosis were studied by indirect immunofluorescence by means of monoclonal antibodies directed at T-cell subsets to find patients with acute exacerbation of MS and patients with continuous progressive deterioration with depressed numbers.
Journal ArticleDOI
Biochemical findings in multiple sclerosis
P. Delmotte,R. Gonsette +1 more
TL;DR: In this article, the authors present evidence that thin layer polyacrylamide isoelectric focusing of the CSF gamma globulins is by far superior for this purpose.
Journal ArticleDOI
Immunoglobulin Abnormalities in Multiple Sclerosis: Relation to Clinical Parameters: Exacerbations and Remissions
Jan-Edvin Olsson,Hans Link +1 more
TL;DR: Variations of the absolute concentrations of Immunoglobulin light chain antigenic determinants of type kappa and lambda during exacerbations and remissions indicate the synthesis within the central nervous system of oligoclonal immunoglobulins with varying light chain type during different phases of the disease.
References
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Thin-layer Gel Filtration.
TL;DR: In this article, the advantages of both Sephadex gel filtration and thin-layer chromatography can now be utilized with the Superfine gel filter for column electrophoresis and partition chromatography.
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Antigenic heterogeneity of human rh antibodies, rheumatoid factors, and cold agglutinins.
TL;DR: Antigenic studies of purified individual 19Sγ-globulin rheumatoid factors and 7S γ- globulin Rh antibodies coating Rh+ cells reveal them to be heterogeneous in their antigenic structure and to contain determinants for antigenic Type I as well as Type II.
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Immunoglobulins in multiple sclerosis and infections of the nervous system.
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